Evidence map›Paper›PMID 36356628›Full record

ReviewThe lancet. Healthy longevity2022

WHO working definition of vitality capacity for healthy longevity monitoring.

Ivan Bautmans, Veerle Knoop, Jotheeswaran Amuthavalli Thiyagarajan, Andrea B Maier, John R Beard, Ellen Freiberger, Daniel Belsky, Mylene Aubertin-Leheudre, Christopher Mikton, Matteo Cesari and 4 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Healthy longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06252844 (The Impact of 6-months of Resistance Training on Intrinsic Capacity, Cognition, and Brain/Circulating Biomarkers of Neuroplasticity and Neuroinflammation in Older Adults With Mild Cognitive Impairment), which is not on this map. Cited by 127 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06252844 naunknown statusnot on this mapstarted 2024, after this paper: background citation

The Impact of 6-months of Resistance Training on Intrinsic Capacity, Cognition, and Brain/Circulating Biomarkers of Neuroplasticity and Neuroinflammation in Older Adults With Mild Cognitive Impairment: a Randomized Controlled Trial.

TypeinterventionalSponsorLithuanian Sports UniversityRan2024 to 2025Enrolled80ConditionsMild Cognitive Impairment, Older Adults at High Risk for MCIArmsResistance exercise training, Active control
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  19. Utilizing the International Classification of Functioning, Disability and Health to Describe Quality-of-Life Assessment in Older Adults in a Middle-Income Country.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ivan BautmansGerontology Department and Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium; Department of Geriatrics, Universitair Ziekenhuis Brussel, Brussels, Belgium. Electronic address: ivan.bautmans@vub.be.
Veerle KnoopGerontology Department and Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium.
Jotheeswaran Amuthavalli ThiyagarajanAgeing and Health Unit, WHO, Geneva, Switzerland.
Andrea B MaierDepartment of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, Australia; Yong Loo Lin School of Medicine, Centre for Healthy Longevity, National University of Singapore, Singapore; National University Health System, Singapore.
John R BeardCentre of Excellence on Population Ageing Research, University of New South Wales, Sydney, NSW, Australia.
Ellen FreibergerInstitute for Biomedicine of Aging, University of Erlangen-Nuremberg, Nuremberg, Germany.
Daniel BelskySocial Science Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Mylene Aubertin-LeheudreCentre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada; Faculty of Sciences, Department of Exercise Sciences, Université du Québec à Montréal, QC, Canada.
Christopher MiktonDemographic Change and Healthy Aging Unit, Social Determinants of Health, WHO, Geneva, Switzerland.
Matteo CesariAgeing and Health Unit, WHO, Geneva, Switzerland.
Yuka SumiAgeing and Health Unit, WHO, Geneva, Switzerland.
Theresa DiazEpidemiology, Monitoring, and Evaluation Units, WHO, Geneva, Switzerland.
Anshu BanerjeeDepartment of Maternal, Newborn, Child, and Adolescent Health and Ageing, WHO, Geneva, Switzerland.
WHO Working Group on Vitality Capacity

Funding

World Health Organization 001
6 · The paper itself

Abstract

Intrinsic capacity, a crucial concept in healthy ageing, is defined by WHO as "the composite of all the physical and mental capacities that an individual can draw on at any point in time". Vitality capacity is considered the underlying physiological determinant of intrinsic capacity. To advance the measurement and monitoring of vitality capacity, a working group of WHO staff members and twenty experts representing six WHO regions was convened to discuss and clarify the attributes of vitality capacity and to develop a clear working definition of the concept. Potential biomarkers to measure vitality capacity were identified, and the following consensual working definition was developed: vitality capacity is a physiological state (due to normal or accelerated biological ageing processes) resulting from the interaction between multiple physiological systems, reflected in (the level of) energy and metabolism, neuromuscular function, and immune and stress response functions of the body.

Indexed as

Healthy AgingLongevityAgingHealth StatusHumansWorld Health Organization

Identifiers

PMID36356628
PMCPMC9640935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.