Evidence map›Paper›PMID 36356627›Full record

ArticleThe lancet. Healthy longevity2022

Association between oral health markers and decline in muscle strength and physical performance in later life: longitudinal analyses of two prospective cohorts from the UK and the USA.

Rachel Kimble, Gillian McLellan, Lucy T Lennon, Anna Olia Papacosta, Robert J Weyant, Yvonne Kapila, John C Mathers, Sasiwarang Goya Wannamathee, Peter H Whincup, Sheena E Ramsay

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in The lancet. Healthy longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Oral virome in health and disease.Journal of the American Dental Association (1939) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
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  8. IntratumoralAnnals of gastroenterological surgery · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Observational
  18. Lifestyles associated with complete tooth loss in elderly people in Brazil, 2019.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Rachel KimblePopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK; Division of Sport and Exercise Science, School of Health and Life Sciences, University of the West of Scotland, Blantyre, UK. Electronic address: rachel.kimble@newcastle.ac.uk.
Gillian McLellanPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Lucy T LennonDepartment of Primary Care and Population Health, University College London, London, UK.
Anna Olia PapacostaDepartment of Primary Care and Population Health, University College London, London, UK.
Robert J WeyantDepartment of Dental Public Health, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Yvonne KapilaSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
John C MathersPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Sasiwarang Goya WannamatheeDepartment of Primary Care and Population Health, University College London, London, UK.
Peter H WhincupPopulation Health Research Institute, St George's, University of London, London, UK.
Sheena E RamsayPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Newcastle University · GBUniversity College London · GBSt George's, University of London · GBUniversity of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studiesR03DE028505 · NIDCR · UNIVERSITY OF NEWCASTLE · PI RAMSAY, SHEENA ESTHER · 2019 to 2020
$213k
British Heart Foundation PG/13/41/30304British Heart Foundation PG/13/86/30546British Heart Foundation RG/08/013/25942British Heart Foundation RG/13/16/30528British Heart Foundation RG/19/4/34452Medical Research Council MR/K006312/1Medical Research Council MR/K02325X/1Medical Research Council MR/L016354/1Medical Research Council MR/P020941/1NIA NIH HHS R01 AG028050NIDCR NIH HHS R03 DE028505NINR NIH HHS R01 NR012459The Dunhill Medical Trust R396/1114The Dunhill Medical Trust R592/0717
6 · The paper itself

Abstract

backgroundPoor oral health could be associated with changes in musculoskeletal health over time. This aim of this study was to investigate the longitudinal relationship between oral health and decline in physical function in later life.

methodsWe did a prospective analysis of two cohorts of older adults (aged 70 years or older) including men from the British Regional Heart Study (BRHS; n=612), and men and women from the Health, Aging and Body Composition (Health ABC) Study (n=1572), followed up for about 8 years. Data were available for clinical or self-reported oral health measures, muscle (grip) strength, and physical performance (chair stand and gait speed). ANCOVA models were used to assess the association between oral health and follow-up physical function scores. Multivariate logistic regression models were used to examine the associations between oral health and decline in physical function over the follow-up period. In the BRHS, changes in oral health and physical function were also assessed. All models were adjusted for relevant sociodemographic, behavioural, and health-related factors.

findingsIn the BRHS, complete tooth loss and difficulty eating were associated with weaker grip strength at follow-up, and periodontal status was associated with decline in gait speed. In the Health ABC Study, complete tooth loss, poor self-rated oral health, and the presence of one oral health problem were associated with slower gait speed at follow-up. In both studies, dry mouth was associated with declines in physical function. In the BRHS, deterioration of dentition (tooth loss) over the follow-up period was associated with decline in chair stand speed (adjusted odds ratio 2·34 [95% CI 1·20-4·46]), as was deterioration in difficulty eating (2·41 [1·04-5·60]).

interpretationOral health problems are associated with poorer physical function and greater decline in physical function in older adults, and could be an indicator of individuals at risk of reduced physical capacity and subsequent frailty and disability in later life.

fundingThe Dunhill Medical Trust and the US National Institutes of Health-National Institute of Dental and Craniofacial Research.

Indexed as

Oral HealthTooth LossAgedFemaleHumansMaleMuscle StrengthPhysical Functional PerformanceUnited Kingdom

Identifiers

PMID36356627
PMCPMC10397540
OpenAlexW4308374259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.