ArticleDevelopmental cognitive neuroscience2022
Developmental aspects of fear generalization - A MEG study on neurocognitive correlates in adolescents versus adults.
Article in Developmental cognitive neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Dynamics of Fear-Generalization Processes and Their Predictive Value for the Development of Anxiety-Related Psychopathology in Adolescents and Adults: A Study Protocol for a Longitudinal Study.International journal of methods in psychiatric research · 2026Article
- Generalized environmental fear hypothesis and the effects of schematic restructuring in autism.Frontiers in psychiatry · 2026Article
- Fear Generalization in Adolescent Anxiety Disorders: A MEG Study.Depression and anxiety · 2026Article
- Psychometric Considerations in Assessing Fear Generalization as a Predictor of Anxiety.Biological psychiatry global open science · 2025Article
- Developmental differences in threat learning are associated with changes in frontal-central theta activity.European child & adolescent psychiatry · 2025Article
- Neurophysiological and Autonomic Dynamics of Threat Processing during Sustained Social Fear Generalization.Journal of cognitive neuroscience · 2025Article
- Neurophysiological and Autonomic Dynamics of Threat Processing During Sustained Social Fear Generalization.bioRxiv : the preprint server for biology · 2024Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundFear generalization is pivotal for the survival-promoting avoidance of potential danger, but, if too pronounced, it promotes pathological anxiety. Similar to adult patients with anxiety disorders, healthy children tend to show overgeneralized fear responses.
objectiveThis study aims to investigate neuro-developmental aspects of fear generalization in adolescence - a critical age for the development of anxiety disorders.
methodsWe compared healthy adolescents (14-17 years) with healthy adults (19-34 years) regarding their fear responses towards tilted Gabor gratings (conditioned stimuli, CS; and slightly differently titled generalization stimuli, GS). In the conditioning phase, CS were paired (CS+) or remained unpaired (CS-) with an aversive stimulus (unconditioned stimuli, US). In the test phase, behavioral, peripheral and neural responses to CS and GS were captured by fear- and UCS expectancy ratings, a perceptual discrimination task, pupil dilation and source estimations of event-related magnetic fields.
resultsClosely resembling adults, adolescents showed robust generalization gradients of fear ratings, pupil dilation, and estimated neural source activity. However, in the UCS expectancy ratings, adolescents revealed shallower generalization gradients indicating overgeneralization. Moreover, adolescents showed stronger visual cortical activity after as compared to before conditioning to all stimuli.
conclusionVarious aspects of fear learning and generalization appear to be mature in healthy adolescents. Yet, cognitive aspects might show a slower course of development.
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