Evidence map›Paper›PMID 36356288›Full record

ArticleChemistry, an Asian journal2022

Sulfone Rhodamines for Voltage Imaging.

Benjamin K Raliski, Dong Min Mun, Evan W Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin K RaliskiDepartment of Chemistry, University of California, Berkeley, 94720-1460, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-6011-8316
Dong Min MunDepartment of Chemistry, University of California, Berkeley, 94720-1460, Berkeley, CA, USA.
Evan W MillerDepartment of Chemistry, University of California, Berkeley, 94720-1460, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-6556-7679

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage SensorsR01NS098088 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Evan Walker Miller · 2017 to 2026
$4.4M
National Institute of General Medical Science T32 GM066698NIGMS NIH HHS T32 GM066698NIHNIH HHSNINDS NIH HHS R01 NS098088NINDS NIH HHS R01NS098088
6 · The paper itself

Abstract

Fluorescent indicators that respond to changes in biological membrane potentials provide a powerful complement to existing methods for monitoring neuronal activity. Indicators that absorb and emit in the near infrared window are especially attractive, since lower energy wavelengths excite fewer biological molecules and can penetrate more deeply into biological tissues. In this work, we incorporate sulfone rhodamine chromophores into a voltage-sensitive scaffold in order to generate voltage sensitive fluorophores which absorb and emit above 700 nm. These Sulfone Rhodamine Voltage Reporters (SuRhoVRs) partition into cell membranes and display good sensitivity to membrane potential changes. The most sensitive SuRhoVR derivative also displays excellent photostability and can track membrane potential changes in dissociated rat hippocampal neurons.

Indexed as

Diagnostic ImagingFluorescent DyesAnimalsRatsRhodaminesSulfonesFluorescent DyesRhodaminesSulfonesfluorescencefluorescent probesmembrane potentialresponsive indicators

Identifiers

PMID36356288
PMCPMC9772261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.