Evidence map›Paper›PMID 36355991›Full record

Trial reportToxins2022

Long-Term Effects of a Single Application of Botulinum Toxin Type A in Temporomandibular Myofascial Pain Patients: A Controlled Clinical Trial.

Giancarlo De la Torre Canales, Mariana Barbosa Câmara-Souza, Rodrigo Lorenzi Poluha, Olívia Maria Costa de Figueredo, Bryanne Brissian de Souza Nobre, Malin Ernberg, Paulo César Rodrigues Conti, Célia Marisa Rizzatti-Barbosa

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Giancarlo De la Torre CanalesClinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz, Cooperativa de Ensino Superior, CRL, 2829-511 Caparica, Portugal.ORCID 0000-0002-0921-342X
Mariana Barbosa Câmara-SouzaIngá University Center, Uningá, Paraná 87015-510, Brazil.ORCID 0000-0002-9961-121X
Rodrigo Lorenzi PoluhaDepartment of Dentistry, State University of Maringa, Paraná 87020-900, Brazil.ORCID 0000-0001-7180-6448
Olívia Maria Costa de FigueredoDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo 13414-903, Brazil.
Bryanne Brissian de Souza NobreIngá University Center, Uningá, Paraná 87015-510, Brazil.
Malin ErnbergDepartment of Dental Medicine, Karolinska Institutet, and the Scandinavian Center for Orofacial Neurosciences (SCON), 141 52 Huddinge, Sweden.ORCID 0000-0003-4152-5439
Paulo César Rodrigues ContiBauru Orofacial Pain Group, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo 17012-900, Brazil.ORCID 0000-0003-0413-4658
Célia Marisa Rizzatti-BarbosaIngá University Center, Uningá, Paraná 87015-510, Brazil.ORCID 0000-0003-1709-2987
Universidade Estadual de Campinas (UNICAMP) · BRKarolinska Institutet · SEUningá - Centro Universitário IngáUniversidade de São Paulo · BRUniversidade Estadual de Maringá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the long-term effects of botulinum toxin type A (BoNT-A) in subjective pain, pain sensibility, and muscle thickness in persistent myofascial temporomandibular-disorder pain (MFP-TMD) patients. Fourteen female subjects with persistent MFP received BoNT-A treatment with different doses (10U-25U for temporalis muscle and 30U-75U for masseter muscle). The treatment was injected bilaterally in the masseter and anterior temporalis muscles in a single session. Clinical measurements included: self-perceived pain (VAS), pain sensibility (PPT), and muscles thickness (ultrasonography). Follow-up occurred 1, 3, 6, and 72 months after treatment for VAS and PPT and 1, 3, and 72 months for ultrasonography. For statistical analysis, the Friedman test with the Bonferroni test for multiple comparisons as a post hoc test was used for non-parametric repeated measures comparisons among the evaluation times. A 5% probability level was considered significant in all tests. VAS values presented a significant decrease throughout the study (

Indexed as

Botulinum Toxins, Type AMyofascial Pain SyndromesTemporomandibular Joint DisordersFemaleHumansPainPain MeasurementTreatment OutcomeBotulinum Toxins, Type Abotulinum toxin type Amuscle thicknessmyofascial paintemporomandibular disorders

Identifiers

PMID36355991
PMCPMC9721314
OpenAlexW4307623795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.