ArticleToxics2022
Flavor Classification/Categorization and Differential Toxicity of Oral Nicotine Pouches (ONPs) in Oral Gingival Epithelial Cells and Bronchial Epithelial Cells.
Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- What is the impact of nicotine pouches on oral health: a systematic review.BMC oral health · 2024Pooled it
- Nicotine-containing products and the cardiovascular system: mechanisms and global health implications.Nature reviews. Cardiology · 2026Review
- Urban-rural disparities in oral nicotine pouch sales and flavors in the United States.The International journal on drug policy · 2026Article
- Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Comparison of Nicotine and Selected Flavoring Contents Between Tobacco-Free and Tobacco-Containing Oral Pouches.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- The association between duration of nicotine pouch use and oral mucosal lesions in male dental students and interns: A cross-sectional study.Tobacco induced diseases · 2026Article
- Self-reported oral health outcomes after switching to a novel nicotine pouch technology: a pilot study.Acta odontologica Scandinavica · 2025Observational
- Oral health effects of non-combustible nicotine products: protocol for a systematic review and network meta-analysis.Systematic reviews · 2025Article
- The Potential Impact of Oral Nicotine Pouches on Public Health: A Scoping Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Assessing Text Messaging Interactivity with a Vaping Cessation Intervention Among Latino Young Adults: A Quantitative and Qualitative Analysis.Substance use & misuse · 2025Article
- Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles forFrontiers in toxicology · 2025Article
- Nicotine pouches: a narrative review of the existing literature.Frontiers in public health · 2025Review
- Oral mucosal changes caused by nicotine pouches: case series.Diagnostic pathology · 2024Article
- Comparative Cytotoxicity of Menthol and Eucalyptol: An In Vitro Study on Human Gingival Fibroblasts.Pharmaceutics · 2024Article
- Tobacco-Free Nicotine Pouches and Their Potential Contribution to Tobacco Harm Reduction: A Scoping Review.Cureus · 2024Article
- Small pouches, but high nicotine doses-nicotine delivery and acute effects after use of tobacco-free nicotine pouches.Frontiers in pharmacology · 2024Article
- Oral nicotine pouches with an aftertaste? Part 1: screening and initial toxicological assessment of flavorings and other ingredients.Archives of toxicology · 2023Article
- Oral nicotine pouches with an aftertaste? Part 2: in vitro toxicity in human gingival fibroblasts.Archives of toxicology · 2023Article
- Classification, Perception, and Toxicity of Emerging Flavored Oral Nicotine Pouches.International journal of environmental research and public health · 2023Review
- Emerging Oral Nicotine Products and Periodontal Diseases.International journal of dentistry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Oral nicotine pouches (ONPs) are a modern form of smokeless tobacco products sold by several brands in the U.S., which comprise a significant portion of non-combustible nicotine-containing product (NCNP) sales to date. ONPs are available in various flavors and may contain either tobacco-derived nicotine (TDN) or tobacco-free nicotine (TFN). The growth in popularity of these products has raised concerns that flavored ONPs may cause adverse oral health effects and promote systemic toxic effects due to nicotine and other ONP by-products being absorbed into the circulatory system through oral mucosa. We hypothesized that flavored ONPs are unsafe and likely to cause oral and pulmonary inflammation in oral and respiratory epithelial cells. Before analyzing the effects of ONPs, we first classified ONPs sold in the U.S. based on their flavor and the flavor category to which they belonged using a wheel diagram.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.