Evidence map›Paper›PMID 36355545›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

"K-Powder" Exposure during Adolescence Elicits Psychiatric Disturbances Associated with Oxidative Stress in Female Rats.

Sabrina de Carvalho Cartágenes, Cinthia Cristina Sousa de Menezes da Silveira, Bruno Gonçalves Pinheiro, Luanna Melo Pereira Fernandes, Sarah Viana Farias, Natália Harumi Correa Kobayashi, Pablo Henrique Franco Santos de Souza, Alejandro Ferraz do Prado, Maria Karolina Martins Ferreira, Rafael Rodrigues Lima and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Sabrina de Carvalho CartágenesLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.
Cinthia Cristina Sousa de Menezes da SilveiraLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.
Bruno Gonçalves PinheiroLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.
Luanna Melo Pereira FernandesLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.ORCID 0000-0001-7004-0719
Sarah Viana FariasLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.ORCID 0000-0002-7201-0609
Natália Harumi Correa KobayashiLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.
Pablo Henrique Franco Santos de SouzaLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.
Alejandro Ferraz do PradoLaboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Science, Federal University of Pará, Belém 66075-900, PA, Brazil.
Maria Karolina Martins FerreiraLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-900, PA, Brazil.
Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-900, PA, Brazil.ORCID 0000-0003-1486-4013
Edivaldo Herculano Correa de OliveiraLaboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.ORCID 0000-0001-6315-3352
Francisco Canindé Ferreira de LunaLaboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Rommel Mário Rodríguez BurbanoLaboratory of Molecular Biology, Ophir Loyola Hospital, Belém 66063-240, PA, Brazil.ORCID 0000-0002-4872-234X
Enéas Andrade Fontes-JúniorLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.ORCID 0000-0002-6186-9581
Cristiane do Socorro Ferraz MaiaLaboratory of Pharmacology of Inflammation and Behavior, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-900, PA, Brazil.ORCID 0000-0003-4493-7375
Universidade Federal do Pará · BRInstituto Evandro Chagas · BRUniversidade do Estado do Pará · BR

Funding

National Council for Scientific and Technological Development 311335/2019-5Research Pro-Rectory of the Federal University of Pará (PROPESP, UFPA, Brazil) EDITAL 02/2022 PAPQ
6 · The paper itself

Abstract

Ketamine, also called 'K-powder' by abusers, an analog of phencyclidine, primarily acts as an antagonist of N-methyl-D-aspartic acid (NMDA) receptors, therapeutically used as an anesthetic agent. Ketamine also stimulates the limbic system, inducing hallucinations and dissociative effects. At sub-anesthetic doses, ketamine also displays hallucinatory and dissociative properties, but not loss of consciousness. These behavioral consequences have elicited its recreational use worldwide, mainly at rave parties. Ketamine is generally a drug of choice among teenagers and young adults; however, the harmful consequences of its recreational use on adolescent central nervous systems are poorly explored. Thus, the aim of the present study was to characterize the behavioral and biochemical consequences induced by one binge-like cycle of ketamine during the early withdrawal period in adolescent female rats. Adolescent female Wistar rats (

Indexed as

adolescentanxietydepressionketamineoxidative stresswithdrawal

Identifiers

PMID36355545
PMCPMC9698848
OpenAlexW4308769163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.