ReviewPharmaceuticals (Basel, Switzerland)2022
Pharmacokinetics and Biological Activity of Cucurbitacins.
Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Opening the black box: study of the multi-target anticancer mechanisms ofRSC advances · 2026Article
- Untargeted LC-QTOF-MS/MS metabolomics and integrative pharmacology identify candidate triterpenoids associated with the gastrointestinal activity of Baliospermum montanum root extract.Inflammopharmacology · 2026Article
- Antihyperglycemic Effects and Molecular Mechanisms ofPlants (Basel, Switzerland) · 2026Review
- Review
- Cucurbitacin derivatives (B, IIa, IIb, and E): modulating gut dysbiosis and inflammatory pathways for multi-target therapy of ulcerative colitis.Inflammopharmacology · 2026Review
- The relationship of cucurbitacin E with epileptic seizures, circadian rhythm, and genetics in a pentylenetetrazole-induced mouse model of epilepsy.Molecular biology reports · 2026Article
- Antifungal efficacy of linoleic-acid-rich Cucurbita pepo L. seed oil revealed by GC-MS profiling of lipids and bioactive markers, ergosterol depletion, and network pharmacology.BMC microbiology · 2026Article
- Hydroalcoholic Extracts ofMolecules (Basel, Switzerland) · 2026Article
- Green extraction and phenolic profiling of bitter melon (Frontiers in nutrition · 2026Article
- Article
- Anti-inflammatory effects of naringinase treated ethanol extracts ofFood science and biotechnology · 2025Article
- Chemical residues in tomato plant tissue andFrontiers in plant science · 2025Article
- Li-Fraumeni Syndrome: Narrative Review Through a Case Report with Ten Years of Primary Tumor Remission Associated withInternational journal of molecular sciences · 2024Review
- Discovery of a lagriamide polyketide by integrated genome mining, isotopic labeling, and untargeted metabolomics.Chemical science · 2024Article
- Depolymerization of actin filaments by Cucurbitacin I through binding G-actin.Food science & nutrition · 2024Article
- A key protein fromIBRO neuroscience reports · 2023Article
- Phytochemicals Target Multiple Metabolic Pathways in Cancer.Antioxidants (Basel, Switzerland) · 2023Review
- Fruit Extract ofNutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and anticancer biological actions. This review addresses pharmacokinetic parameters recently reported, including absorption, metabolism, distribution, and elimination phases of cucurbitacins. It includes recent studies of the molecular mechanisms of the biological activity of the most studied cucurbitacins and some derivatives, especially their anticancer capacity, to propose the integration of the pharmacokinetic profiles of cucurbitacins and the possibilities of their use. The main botanical genera and species of American origin that have been studied, and others whose chemo taxonomy makes them essential sources for the extraction of these metabolites, are summarized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.