Evidence map›Paper›PMID 36355427›Full record

ArticleGlobal spine journal2024

Hypertrophic Ligamentum Flavum in Lumbar Spine Stenosis Is Associated With the Increased Expression of Secreted Protein Acidic and Rich in Cysteine.

Ching-Yu Lee, Meng-Huang Wu, Tsung-Jen Huang, Po-Yao Wang, Alexander T H Wu

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Article in Global spine journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ching-Yu LeeDepartment of Orthopedics, Taipei Medical University Hospital, Taipei, Taiwan.ORCID 0000-0001-6118-1667
Meng-Huang WuDepartment of Orthopedics, Taipei Medical University Hospital, Taipei, Taiwan.ORCID 0000-0003-1606-2444
Tsung-Jen HuangDepartment of Orthopedics, Taipei Medical University Hospital, Taipei, Taiwan.
Po-Yao WangDepartment of Orthopedics, Taipei Medical University Hospital, Taipei, Taiwan.ORCID 0000-0003-1012-6953
Alexander T H WuTMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-0178-6530

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designBasic research.

objectivesSecreted protein acidic and rich in cysteine (SPARC) is a critical pro-fibrotic mediator. This study aims to characterize the role of SPARC in hypertrophic ligamentum flavum (LF) and fibrosis.

methodsHypertrophic LF samples were obtained from 8 patients with L4/5 lumbar spinal stenosis (LSS) during the decompressive laminectomy. Non-hypertrophic LF from age- and sex-matched 8 patients with L4/5 lumbar disc herniation was selected as control. An in vitro model of fibrosis in human LF cells was established by interleukin 6 (IL-6) to assess SPARC expression.

resultsHypertrophic LF samples had higher fibrosis scores than control samples by Masson's trichrome staining (3.6 vs. 1.3,

conclusionSPARC was detected in human LF and significantly upregulated in the clinical samples of hypertrophic LF compared to their normal counterparts. We also demonstrated an increased level of SPARC in an in vitro fibrosis model of LF. Thus, SPARC could be a crucial biomarker for the pathogenesis of hypertrophic LF and a therapeutic target for LSS.

Indexed as

fibrosishypertrophic ligamentum flavumlumbar spinal stenosisSecreted protein acidic and rich in cysteine

Identifiers

PMID36355427
PMCPMC11289542

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