Evidence map›Paper›PMID 36355304›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Small-Animal Compression Models of Osteoarthritis.

Blaine A Christiansen, Deva D Chan, Marjolein C H van der Meulen, Tristan Maerz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. [Pathology of Cartilage-to-Bone Crosstalk: A New Angle for Animal Experimental Studies on Osteoarthritis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Blaine A ChristiansenUniversity of California Davis Health, Department of Orthopaedic Surgery, Sacramento, CA, USA. bchristiansen@ucdavis.edu.
Deva D ChanPurdue University, Weldon School of Biomedical Engineering, West Lafayette, IN, USA.
Marjolein C H van der MeulenCornell University, Meinig School of Biomedical Engineering and Sibley School of Mechanical & Aerospace Engineering, Ithaca, NY, USA.
Tristan MaerzUniversity of Michigan, Departments of Orthopaedic Surgery and Biomedical Engineering, Ann Arbor, MI, USA.
Cornell University · USPurdue University West Lafayette · USUniversity of California, Davis · USUniversity of Michigan–Ann Arbor · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Modification of Post-Traumatic Osteoarthritis Progression with Joint UnloadingR01AR075013 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHRISTIANSEN, BLAINE A. · 2020 to 2024
$2.7M
Mechanisms of Systemic Bone Loss Following Femur Fracture in MiceR01AR071459 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHRISTIANSEN, BLAINE A. · 2017 to 2021
$1.8M
Enhancing adaptation to loading with PTH in osteoporosisR21AR071587 · NIAMS · CORNELL UNIVERSITY · PI VAN DER MEULEN, MARJOLEIN C · 2017 to 2018
$385k
NCATS NIH HHS UL1 TR002529NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR071459NIAMS NIH HHS R01 AR075013NIAMS NIH HHS R21 AR071587
6 · The paper itself

Abstract

The utility of nonsurgical, mechanical compression-based joint injury models to study osteoarthritis pathogenesis and treatments is increasing. Joint injury may be induced via cyclic compression loading or acute overloading to induce anterior cruciate ligament rupture. Models utilizing mechanical testing systems are highly repeatable, require little expertise, and result in a predictable onset of osteoarthritis-like pathology on a rapidly progressing timeline. In this chapter, we describe the procedures and equipment needed to perform mechanical compression-induced initiation of osteoarthritis in mice and rats.

Indexed as

Anterior Cruciate Ligament InjuriesCartilage, ArticularOsteoarthritisAnimalsDisease Models, AnimalMiceRatsAnimal modelsAnterior cruciate ligamentCartilageCompressionInjuryOsteoarthritisPost-traumatic

Identifiers

PMID36355304
PMCPMC10521326
OpenAlexW4308907423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.