Evidence map›Paper›PMID 36355290›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Metabolomic Profiling to Understand Chondrocyte Metabolism.

Priyanka P Brahmachary, Hope D Welhaven, Ronald K June

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Priyanka P Brahmachary *Department of Mechanical & Industrial Engineering, Montana State University, Bozeman, MT, USA.
Hope D Welhaven *Molecular Biosciences Program, Montana State University, Bozeman, MT, USA.
Ronald K JuneDepartment of Mechanical & Industrial Engineering, Montana State University, Bozeman, MT, USA. rjune@montana.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolism has long been recognized as a critical physiological process necessary to maintain homeostasis in all types of cells including the chondrocytes of articular cartilage. Alterations in metabolism in disease and metabolic adaptation to physiological stimuli such as mechanical loading are increasingly recognized as important for understanding musculoskeletal systems such as synovial joints. Metabolomics is an emerging technique that allows quantitative measurement of thousands of small molecule metabolites that serve as both products and reactants to myriad reactions of cellular biochemistry. This protocol describes procedures to perform metabolomic profiling on chondrocytes and other tissues and fluids within the synovial joint.

Indexed as

Cartilage, ArticularOsteoarthritisChondrocytesHomeostasisHumansMetabolomicsCartilageMetabolite extractionMetabolomic profilingMetabolomicsOsteoarthritisSynovial fluid

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.