Evidence map›Paper›PMID 36355279›Full record

ArticleJournal of microbiology (Seoul, Korea)2022

Functional analysis of ascP in Aeromonas veronii TH0426 reveals a key role in the regulation of virulence.

Yongchao Guan, Meng Zhang, Yingda Wang, Zhongzhuo Liu, Zelin Zhao, Hong Wang, Dingjie An, Aidong Qian, Yuanhuan Kang, Wuwen Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongchao GuanCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Meng ZhangCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Yingda WangCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Zhongzhuo LiuCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Zelin ZhaoCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Hong WangCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Dingjie AnCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Aidong QianCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Yuanhuan KangCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China.
Wuwen SunCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China. sunwuwensci@163.com.
Xiaofeng ShanCollege of Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, P. R. China. sxf1997@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aeromonas veronii is a pathogen which can induce diseases in humans, animals and aquatic organisms, but its pathogenic mechanism and virulence factors are still elusive. In this study, we successfully constructed a mutant strain (ΔascP) by homologous recombination. The results showed that the deletion of the ascP gene significantly down-regulated the expression of associated effector proteins in A. veronii compared to its wild type. The adhesive and invasive abilities of ΔascP to EPC cells were 0.82-fold lower in contrast to the wild strain. The toxicity of ΔascP to cells was decreased by about 2.91-fold (1 h) and 1.74-fold (2 h). Furthermore, the LD

Indexed as

CarpsFish DiseasesGram-Negative Bacterial InfectionsAeromonas veroniiAnimalsHumansVirulenceVirulence FactorsVirulence FactorsAeromonas veroniiascP geneT3SSvirulence

Identifiers

PMID36355279
PMCPMC9647756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.