Evidence map›Paper›PMID 36355138›Full record

ArticleMetabolites2022

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer's Disease.

Mater H Mahnashi, Mohammed Abdulrahman Alshahrani, Mohammed H Nahari, Syed Shams Ul Hassan, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Osama M Alshehri, Mohammad Ali Alshehri, Umer Rashid and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Effects of APOE4 on omega-3 brain metabolism across the lifespan.Trends in endocrinology and metabolism: TEM · 2024
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  16. Phenolic phytochemistry,Frontiers in pharmacology · 2024
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  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mater H MahnashiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 61441, Saudi Arabia.ORCID 0000-0002-4837-3653
Mohammed Abdulrahman AlshahraniDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.
Mohammed H NahariDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.ORCID 0000-0002-3499-4678
Syed Shams Ul HassanShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-5188-6540
Muhammad Saeed JanDepartment of Pharmacy, Bacha Khan University, Charsadda 24420, KP, Pakistan.ORCID 0000-0003-2411-6510
Muhammad AyazDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Dir (L), Chakdara 18000, KP, Pakistan.
Farhat UllahDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Dir (L), Chakdara 18000, KP, Pakistan.
Osama M AlshehriDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.ORCID 0000-0002-5498-0687
Mohammad Ali AlshehriMedical Genetics Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, KP, Pakistan.
Abdul SadiqDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Dir (L), Chakdara 18000, KP, Pakistan.

Funding

HEC-NRPU 5291/Federal/NRPU/R&D/HEC/2016Najran University NU/IF/INT/01/007
6 · The paper itself

Abstract

Plants' bioactives are well-known safe drugs for vital diseases. Flavones and Flavonoid-rich dietary supplements are known to exhibit neuroprotective potential. In this study, we isolated a flavone 2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-4H-chromen-4-one from

Indexed as

cholinesterasesflavoneinflammationNotholirion thomsonianumoxidative stress

Identifiers

PMID36355138
PMCPMC9694897

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.