Evidence map›Paper›PMID 36355133›Full record

ArticleMetabolites2022

Butin Mitigates Memory Impairment in Streptozotocin-Induced Diabetic Rats by Inhibiting Oxidative Stress and Inflammatory Responses.

Asma B Omer, Mahmood Hassan Dalhat, Mohammad Kaleem Khan, Obaid Afzal, Abdulmalik S A Altamimi, Sami I Alzarea, Waleed Hassan Almalki, Imran Kazmi

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Asma B OmerDepartment of Basic Health Sciences, Foundation Year for the Health Colleges, Princess Nourah bint Abdul Rahman University, Riyadh 11671, Saudi Arabia.
Mahmood Hassan DalhatDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mohammad Kaleem KhanDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Obaid AfzalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.ORCID 0000-0002-4188-5592
Abdulmalik S A AltamimiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Sami I AlzareaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
Waleed Hassan AlmalkiDepartment of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Imran KazmiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-1881-5219
King Abdulaziz University · SAPrince Sattam Bin Abdulaziz University · SAJouf University · SAPrincess Nourah bint Abdulrahman University · SAUmm al-Qura University · SA

Funding

Umm al-Qura University 224UQU4310387DSR03.
6 · The paper itself

Abstract

It has been reported from the previous literature that butin restores mitochondrial dysfunction by modulation of oxidative stress and glutamate-induced neurotoxicity in mouse hippocampus HT22 cells. Butin also possesses an anti-Huntington's effect in rats. Considering the current background, this study was designed to evaluate the neuroprotective effect of butin against memory loss caused by streptozotocin (STZ). STZ (40 mg/kg) was intraperitoneally injected into rats. Three days later, diabetic rats were identified and included in the study. A total of 30 rats (12 nondiabetic and 18 diabetics) were grouped as Group A (control-non-diabetic rats) and Group B (STZ diabetic control) were treated with 1 mL of sodium CMC (0.5%

Indexed as

acetylcholinesterasebutinflavonoidsneuroprotectivestreptozotocin

Identifiers

PMID36355133
PMCPMC9694489
OpenAlexW4308764419

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.