Evidence map›Paper›PMID 36354982›Full record

ArticleMarine drugs2022

Carbon Source Influences Antioxidant, Antiglycemic, and Antilipidemic Activities of

Micaela Giani, Luigia Gervasi, Monica Rosa Loizzo, Rosa María Martínez-Espinosa

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Bacterioruberin fromInternational journal of molecular sciences · 2026
    Article
  2. A New Era for Using Natural Pigments: The Case of the CBiotechnology and applied biochemistry · 2026
    Review
  3. Recent Advances in Understanding Bio-Compounds from Haloarchaea.Journal of microbiology and biotechnology · 2026
    Review
  4. Article
  5. Article
  6. Bacterioruberin (CNutrients · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Microbial Bacterioruberin: A Comprehensive Review.Indian journal of microbiology · 2024
    Review
  11. Article
  12. Article
  13. Extreme halophilicHeliyon · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Some novel bioactivities ofSaudi journal of biological sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Micaela GianiBiochemistry and Molecular Biology Division, Agrochemistry and Biochemistry Department, Faculty of Sciences, University of Alicante, Ap. 99, E-03080 Alicante, Spain.ORCID 0000-0002-7558-7278
Luigia GervasiDepartment of Pharmacy, Health Science and Nutrition, University of Calabria, I-87036 Arcavacata Rende, Italy.
Monica Rosa LoizzoDepartment of Pharmacy, Health Science and Nutrition, University of Calabria, I-87036 Arcavacata Rende, Italy.ORCID 0000-0002-6050-9357
Rosa María Martínez-EspinosaBiochemistry and Molecular Biology Division, Agrochemistry and Biochemistry Department, Faculty of Sciences, University of Alicante, Ap. 99, E-03080 Alicante, Spain.ORCID 0000-0003-2679-135X
University of Alicante · ESUniversity of Calabria · IT

Funding

European Molecular Biology Organization 8977Generalitat Valenciana ACIF/2019/043Generalitat Valenciana PROMETEO/2021/055Ministry of Economy, Industry and Competitiveness RTI2018-099860-B- 316 I00University of Alicante VIGROB-309
6 · The paper itself

Abstract

Haloarchaeal carotenoids have attracted attention lately due to their potential antioxidant activity. This work studies the effect of different concentrations of carbon sources on cell growth and carotenoid production. Carotenoid extract composition was characterized by HPLC-MS. Antioxidant activity of carotenoid extracts obtained from cell cultures grown under different nutritional conditions was determined by 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH), Ferric Reducing Ability Power (FRAP) and β-carotene bleaching assays. The ability of these carotenoid extracts to inhibit α-glucosidase, α-amylase, and lipase enzymes was also assessed to determine if they could be used to reduce blood glucose and lipid absorption. The maximum production of carotenoids (92.2 µg/mL) was observed combining 12.5% inorganic salts and 2.5% of glucose/starch. Antioxidant, hypoglycemic, and antilipidemic studies showed that higher carbon availability in the culture media leads to changes in the extract composition, resulting in more active haloarchaeal carotenoid extracts. Carotenoid extracts obtained from high-carbon-availability cell cultures presented higher proportions of all-

Indexed as

AntioxidantsHaloferax mediterraneiCarbonCarotenoidsPlant ExtractsAntioxidantsbacterioruberinCarbonCarotenoidsPlant ExtractsbacterioruberincarotenoidshaloarchaeaHaloferax mediterraneihyperglycemiaobesity

Identifiers

PMID36354982
PMCPMC9697119
OpenAlexW4307262488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.