Evidence map›Paper›PMID 36354876›Full record

ReviewJournal of imaging2022

Harmonization Strategies in Multicenter MRI-Based Radiomics.

Elisavet Stamoulou, Constantinos Spanakis, Georgios C Manikis, Georgia Karanasiou, Grigoris Grigoriadis, Theodoros Foukakis, Manolis Tsiknakis, Dimitrios I Fotiadis, Kostas Marias

Abstract readReview
In one paragraph

Review in Journal of imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Radiomics and Back Pain.Global spine journal · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Uncertainties in outcome modelling in radiation oncology.Physics and imaging in radiation oncology · 2025
    Review
  18. The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA-Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elisavet StamoulouComputational BioMedicine Laboratory (CBML), Foundation for Research and Technology-Hellas (FORTH), 700 13 Heraklion, Greece.
Constantinos SpanakisComputational BioMedicine Laboratory (CBML), Foundation for Research and Technology-Hellas (FORTH), 700 13 Heraklion, Greece.ORCID 0000-0002-7830-1255
Georgios C ManikisComputational BioMedicine Laboratory (CBML), Foundation for Research and Technology-Hellas (FORTH), 700 13 Heraklion, Greece.ORCID 0000-0002-3396-0644
Georgia KaranasiouUnit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, 451 10 Ioannina, Greece.ORCID 0000-0001-9478-0375
Grigoris GrigoriadisUnit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, 451 10 Ioannina, Greece.
Theodoros FoukakisDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0001-8952-9987
Manolis TsiknakisComputational BioMedicine Laboratory (CBML), Foundation for Research and Technology-Hellas (FORTH), 700 13 Heraklion, Greece.ORCID 0000-0001-8454-1450
Dimitrios I FotiadisUnit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, 451 10 Ioannina, Greece.
Kostas MariasComputational BioMedicine Laboratory (CBML), Foundation for Research and Technology-Hellas (FORTH), 700 13 Heraklion, Greece.

Funding

European Union's Horizon 2020 research and innovation programme 945175 (CARDIOCARE)
6 · The paper itself

Abstract

Radiomics analysis is a powerful tool aiming to provide diagnostic and prognostic patient information directly from images that are decoded into handcrafted features, comprising descriptors of shape, size and textural patterns. Although radiomics is gaining momentum since it holds great promise for accelerating digital diagnostics, it is susceptible to bias and variation due to numerous inter-patient factors (e.g., patient age and gender) as well as inter-scanner ones (different protocol acquisition depending on the scanner center). A variety of image and feature based harmonization methods has been developed to compensate for these effects; however, to the best of our knowledge, none of these techniques has been established as the most effective in the analysis pipeline so far. To this end, this review provides an overview of the challenges in optimizing radiomics analysis, and a concise summary of the most relevant harmonization techniques, aiming to provide a thorough guide to the radiomics harmonization process.

Indexed as

batch effectfeature harmonizationfeature stabilityimage harmonizationMRImulticenter studiesradiomicsstandardizationvariability

Identifiers

PMID36354876
PMCPMC9695920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.