Evidence map›Paper›PMID 36354619›Full record

ArticleGels (Basel, Switzerland)2022

Low Release Study of Cefotaxime by Functionalized Mesoporous Silica Nanomaterials.

Dan Eduard Mihaiescu, Daniela Istrati, Alina Moroșan, Maria Stanca, Bogdan Purcăreanu, Rodica Cristescu, Bogdan Ștefan Vasile, Roxana Doina Trușca

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dan Eduard MihaiescuDepartment of Organic Chemistry "Costin Nenitescu", Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Daniela IstratiDepartment of Organic Chemistry "Costin Nenitescu", Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Alina MoroșanDepartment of Organic Chemistry "Costin Nenitescu", Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-1437-6570
Maria StancaLeather and Footwear Research Institute, 031215 Bucharest, Romania.ORCID 0000-0002-8920-9040
Bogdan PurcăreanuFaculty of Chemical Engineering and Biotechnologies, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-9075-9429
Rodica CristescuLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania.ORCID 0000-0002-3092-6168
Bogdan Ștefan VasileFaculty of Chemical Engineering and Biotechnologies, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-2267-6453
Roxana Doina TrușcaFaculty of Chemical Engineering and Biotechnologies, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.

Funding

BIOMATE PN-III-P4-ID-PCE-2016-0884 / 2017PROZECHIMED PN-III-P2-2.1-PTE-2016-0160, 49-PTE / 2016
6 · The paper itself

Abstract

As a third-generation β-lactam antibiotic, cefotaxime shows a broad-spectrum with Gram-positive and Gram-negative bacteria activity and is included in WHO's essential drug list. In order to obtain new materials with sustained release properties, the present research focuses on the study of cefotaxime absorption and desorption from different functionalized mesoporous silica supports. The MCM-41-type nanostructured mesoporous silica support was synthesized by sol-gel technique using a tetraethyl orthosilicate (TEOS) route and cetyltrimethylammonium bromide (CTAB) as a surfactant, at room temperature and normal pressure. The obtained mesoporous material (MCM-41 class) was characterized through nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), N

Indexed as

cefotaximelow releaseMCM-41mesoporous materialsol–gel

Identifiers

PMID36354619
PMCPMC9689901

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.