ArticleBioengineering (Basel, Switzerland)2022
Gait Initiation Impairment in Patients with Parkinson's Disease and Freezing of Gait.
Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Effects of Manual Therapy on Parkinson's Gait: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Pooled it
- Freezing of gait and the effects of vibrotactile cueing in Parkinson's disease-a study protocol of a cross-sectional multimodal brain imaging approach in virtual walking scenarios.Frontiers in neuroscience · 2026Article
- Surface electromyographic profiles during gait initiation in people with Parkinson's disease: The effects of external sensory cueing.Journal of Parkinson's disease · 2025Article
- Capturing Compensatory Reserve in Sarcopenia: A Bioengineering Framework for Multidimensional Temporal Analysis of Center-of-Pressure Signals.Bioengineering (Basel, Switzerland) · 2025Article
- Stability vs. performance: The role of weight shift during gait initiation for people with Parkinson disease.Journal of biomechanics · 2025Article
- Principal Component Analysis Enhanced with Bootstrapped Confidence Interval for the Classification of Parkinsonian Patients Using Gaussian Mixture Model and Gait Initiation Parameters.Sensors (Basel, Switzerland) · 2024Article
- Color-induced cognitive conflicts affect muscle activity prior to gait initiation in the Go/No-go task.Frontiers in human neuroscience · 2024Article
- Case report: Improvement of gait with adaptive deep brain stimulation in a patient with Parkinson's disease.Frontiers in bioengineering and biotechnology · 2024Article
- Correlation of balance posturographic parameters during quiet standing with the berg balance scale in patients with parkinson's disease.BMC neurology · 2023Article
- Balance assessment in selected stages of Parkinson's disease using trend change analysis.Journal of neuroengineering and rehabilitation · 2023Observational
- Advances in Biomechanics-Based Motion Analysis.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Freezing of gait (FOG) is a sudden episodic inability to produce effective stepping despite the intention to walk. It typically occurs during gait initiation (GI) or modulation and may lead to falls. We studied the anticipatory postural adjustments (imbalance, unloading, and stepping phase) at GI in 23 patients with Parkinson's disease (PD) and FOG (PDF), 20 patients with PD and no previous history of FOG (PDNF), and 23 healthy controls (HCs). Patients performed the task when off dopaminergic medications. The center of pressure (CoP) displacement and velocity during imbalance showed significant impairment in both PDNF and PDF, more prominent in the latter patients. Several measurements were specifically impaired in PDF patients, especially the CoP displacement along the anteroposterior axis during unloading. The pattern of segmental center of mass (SCoM) movements did not show differences between groups. The standing postural profile preceding GI did not correlate with outcome measurements. We have shown impaired motor programming at GI in Parkinsonian patients. The more prominent deterioration of unloading in PDF patients might suggest impaired processing and integration of somatosensory information subserving GI. The unaltered temporal movement sequencing of SCoM might indicate some compensatory cerebellar mechanisms triggering time-locked models of body mechanics in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.