Evidence map›Paper›PMID 36354349›Full record

ArticleAntimicrobial agents and chemotherapy2022

Multiple Genes of Candida albicans Influencing Echinocandin Susceptibility in Caspofungin-Adapted Mutants.

Sudisht K Sah, Soumyaroop Bhattacharya, Anshuman Yadav, Farha Husain, Aissatou B K T Ndiaye, Michael D Kruppa, Jeffrey J Hayes, Elena Rustchenko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Echinocandin Adaptation inJournal of fungi (Basel, Switzerland) · 2025
    Article
  2. An Evolved Strain of the Oleaginous YeastJournal of fungi (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Microorganisms · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sudisht K SahDepartment of Biochemistry and Biophysics, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.
Soumyaroop BhattacharyaDepartment of Medicine, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.
Anshuman YadavDepartment of Biochemistry and Biophysics, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.
Farha HusainDepartment of Biochemistry and Biophysics, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.
Aissatou B K T NdiayeDepartment of Biochemistry and Biophysics, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.
Michael D KruppaDepartment of Biomedical Sciences, Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State Universitygrid.255381.8, Johnson City, Tennessee, USA.
Jeffrey J HayesDepartment of Biochemistry and Biophysics, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.
Elena RustchenkoDepartment of Biochemistry and Biophysics, University of Rochester Medical Centergrid.412750.5, Rochester, New York, USA.ORCID 0000-0002-4854-4985
University of Rochester Medical Center · USEast Tennessee State University · US

Funding

Histone Tall Interactions and Functions in ChromatinR01GM052426 · NIGMS · UNIVERSITY OF ROCHESTER · PI HAYES, JEFFREY J · 1995 to 2021
$6.2M
Molecular mechanisms of caspofungin susceptibility in the pathogen Candida albicansR01AI141884 · NIAID · UNIVERSITY OF ROCHESTER · PI RUSTCHENKO, ELENA · 2019 to 2023
$1.9M
Molecular mechanisms of caspofungin resistance in the pathogen Candida albicansR01AI110764 · NIAID · UNIVERSITY OF ROCHESTER · PI RUSTCHENKO, ELENA · 2014 to 2016
$1.0M
Genetic Characterization of phosphomannan biosynthesis in C. aurisR21AI159877 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI KRUPPA, MICHAEL D · 2021 to 2022
$407k
HHS | National Institutes of Health (NIH) R01AI110764NIAID NIH HHS R01 AI110764NIAID NIH HHS R01 AI141884NIAID NIH HHS R21 AI159877NIGMS NIH HHS R01 GM052426
6 · The paper itself

Abstract

Candida albicans is an opportunistic human fungal pathogen that causes invasive infections in immunocompromised individuals. Despite the high anticandidal activity among the echinocandins (ECNs), a first-line therapy, resistance remains an issue. Furthermore, many clinical isolates display decreased ECN susceptibility, a physiological state which is thought to lead to resistance. Determining the factors that can decrease susceptibility is of high importance. We searched for such factors genome-wide by comparing the transcriptional profiles of five mutants that acquired decreased caspofungin susceptibility

Indexed as

Candida albicansEchinocandinsAntifungal AgentsCaspofunginDrug Resistance, FungalFungal ProteinsLipopeptidesMicrobial Sensitivity TestsAntifungal AgentsCaspofunginEchinocandinsFungal ProteinsLipopeptidesCandida albicansdrug adaptationdrug toleranceechinocandin susceptibilityRNA profiling

Identifiers

PMID36354349
PMCPMC9765025
OpenAlexW4308685596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.