Evidence map›Paper›PMID 36354341›Full record

ArticleJournal of virology2022

Macrophage Depletion Reactivates Fecal Virus Shedding following Resolution of Acute Hepatitis A in

Tomoyuki Shiota, Mami Matsuda, Xin Zheng, Noriyo Nagata, Koji Ishii, Ryosuke Suzuki, Masamichi Muramatsu, Kazuhiro Takimoto, Ken-Ichi Hanaki, Stanley M Lemon and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Advances and perspectives in animal models of human hepatitis A virus.Animal models and experimental medicine · 2026
    Review
  2. An engineered human hepatitis A virus capable of rapid proliferationJHEP reports : innovation in hepatology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Tomoyuki ShiotaDepartment of Virology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Mami MatsudaDepartment of Virology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Xin ZhengDepartment of Virology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Noriyo NagataDepartment of Pathology, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Koji IshiiDepartment of Virology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Ryosuke SuzukiDepartment of Virology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.ORCID 0000-0003-0296-8843
Masamichi MuramatsuDepartment of Virology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.ORCID 0000-0002-0153-3533
Kazuhiro TakimotoManagement Department of Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Ken-Ichi HanakiManagement Department of Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Stanley M LemonLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1450-806X
David R McGivernLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3497-5087
Asuka Hirai-YukiManagement Department of Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.ORCID 0000-0002-1218-8333
National Institute of Infectious Diseases · JPUniversity of North Carolina at Chapel Hill · US

Funding

Membrane Hijacking: Biogenesis and Fate of Quasi-Enveloped HepatovirusR01AI103083 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M. · 2012 to 2021
$4.0M
Critical Lipid Species in the Hepatovirus LifecycleR01AI150095 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M. · 2020 to 2024
$2.6M
Murine Model of Human Hepatitis AR01AI131685 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M., WHITMIRE, JASON KYLE · 2017 to 2021
$1.9M
NIAID NIH HHS R01 AI103083NIAID NIH HHS R01 AI131685NIAID NIH HHS R01 AI150095
6 · The paper itself

Abstract

Although hepatitis A virus (HAV) is associated only with acute hepatitis in humans, HAV RNA persists within the liver for months following resolution of liver inflammation and cessation of fecal virus shedding in chimpanzees and murine models of hepatitis A. Here, we confirm striking differences in the kinetics of HAV RNA clearance from liver versus serum and feces in infected

Indexed as

Hepatitis AHepatitis A virusMacrophagesVirus SheddingAnimalsCD8-Positive T-LymphocytesFecesInflammationMiceMice, KnockoutReceptor, Interferon alpha-betaRNA, ViralIfnar1 protein, mouseReceptor, Interferon alpha-betaRNA, Viralhepatitis A virusmacrophagespersistent intrahepatic HAV RNA

Identifiers

PMID36354341
PMCPMC9749467
OpenAlexW4308682716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.