Evidence map›Paper›PMID 36354315›Full record

ReviewFuture cardiology2023

Anthracycline chemotherapy, vascular dysfunction and cognitive impairment: burgeoning topics and future directions.

Grace S Maurer, Zachary S Clayton

Open access · greenAbstract readReview
In one paragraph

Review in Future cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Grace S MaurerDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.
Zachary S ClaytonDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.ORCID 0000-0003-3878-3533
University of Colorado Boulder · US

Funding

TRAINING IN RENAL &ELECTROLYTE DISEASE &HYPERTENSIONT32DK007135 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, RICHARD JOSEPH, KENDRICK, JESSICA B · 1986 to 2024
$5.3M
Translational studies of cellular senescence as a regulator of doxorubicin-mediated arterial dysfunctionK99HL159241 · NHLBI · UNIVERSITY OF COLORADO · PI CLAYTON, ZACHARY S. · 2022 to 2023
$350k
Mitochondrial oxidative stress: a target for treatment of doxorubicin-associated vascular endothelial dysfunctionF32HL151022 · NHLBI · UNIVERSITY OF COLORADO · PI CLAYTON, ZACHARY S. · 2020 to 2021
$89k
NHLBI NIH HHS F32 HL151022NHLBI NIH HHS K99 HL159241NIDDK NIH HHS T32 DK007135NIH HHS F32 HL151022, K99 HL159241, T32 DK007135
6 · The paper itself

Abstract

Anthracyclines, chemotherapeutic agents used to treat common forms of cancer, increase cardiovascular (CV) complications, thereby necessitating research regarding interventions to improve the health of cancer survivors. Vascular dysfunction, which is induced by anthracycline chemotherapy, is an established antecedent to overt CV diseases. Potential treatment options for ameliorating vascular dysfunction have largely been understudied. Furthermore, patients treated with anthracyclines have impaired cognitive function and vascular dysfunction is an independent risk factor for the development of mild cognitive impairment. Here, we will focus on: anthracycline chemotherapy associated CV diseases risk; how targeting mechanisms underlying vascular dysfunction may be a means to improve both CV and cognitive health; and research gaps and potential future directions for the field of cardio-oncology.

Indexed as

Cardiovascular DiseasesCognitive DysfunctionNeoplasmsAnthracyclinesAntibiotics, AntineoplasticCardiotoxicityHumansAnthracyclinesAntibiotics, Antineoplasticarterial functioncancercardio-oncologycardiovascular diseasedoxorubicintherapeutic strategies

Identifiers

PMID36354315
PMCPMC10599408
OpenAlexW4308683214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.