Evidence map›Paper›PMID 36354189›Full record

ArticleThe journal of physical chemistry. B2022

Transient On- and Off-Pathway Protein Folding Intermediate States Characterized with NMR Relaxation Dispersion.

Derrick W Meinhold, Daniel J Felitsky, H Jane Dyson, Peter E Wright

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Derrick W MeinholdDepartment of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037, United States.
Daniel J FelitskyDepartment of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037, United States.
H Jane DysonDepartment of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037, United States.ORCID 0000-0001-6855-3398
Peter E WrightDepartment of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037, United States.ORCID 0000-0002-1368-0223
Scripps Research Institute · US

Funding

Structural Characterization of Globin Folding PathwaysR01DK034909 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI WRIGHT, PETER EDWIN · 1986 to 2017
$4.8M
Structural Studies of Large Dynamic ComplexesR35GM131693 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DYSON, HELEN JANE · 2019 to 2023
$2.6M
STRUCTURAL CHARACTERIZATION OF GLOBIN FOLDING PATHWAYSR37DK034909 · NIDDK · SCRIPPS RESEARCH INSTITUTE · PI WRIGHT, PETER EDWIN · 1994 to 2001
$559k
Probing the Structure of Transient Unfolded States with NMR Relaxation DispersionF32GM084594 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI MEINHOLD, DERRICK WALTER · 2008 to 2010
$149k
Structural Origins of Cooperativity in Molten Globule FormationF32GM075713 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI FELITSKY, DANIEL J · 2005 to 2006
$93k
NIDDK NIH HHS R01 DK034909NIDDK NIH HHS R37 DK034909NIGMS NIH HHS F32 GM075713NIGMS NIH HHS F32 GM084594NIGMS NIH HHS R35 GM131693
6 · The paper itself

Abstract

The earliest events in the folding of a protein are in general poorly understood. We used NMR

Indexed as

ApoproteinsProtein FoldingKineticsMagnetic Resonance SpectroscopyMutant ProteinsMyoglobinProtein Structure, SecondaryApoproteinsMutant ProteinsMyoglobin

Identifiers

PMID36354189
PMCPMC9793904
OpenAlexW4308667317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.