Evidence map›Paper›PMID 36354140›Full record

ArticleAnnals of medicine2022

Plasma thrombomodulin levels are associated with acute kidney injury in patients with acute heart failure.

Shu-Min Lin, Chih-Hsiang Chang, Ting-Yu Lin, Allen Chung-Cheng Huang, Chiung-Hung Lin, Yung-Chang Chen, Pao-Hsien Chu

Abstract read
In one paragraph

Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shu-Min LinDepartment of Thoracic Medicine, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
Chih-Hsiang ChangDepartment of Nephrology, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
Ting-Yu LinDepartment of Thoracic Medicine, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.ORCID 0000-0002-4193-0728
Allen Chung-Cheng HuangDepartment of Thoracic Medicine, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
Chiung-Hung LinDepartment of Thoracic Medicine, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
Yung-Chang ChenDepartment of Nephrology, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
Pao-Hsien ChuDepartment of Cardiology, School of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiorenal syndrome type I (CRS I) is defined as the development of acute kidney injury (AKI) following acute decompensated heart failure (ADHF). The clinical significance of endothelial markers in ADHF-associated AKI has yet to be clarified. This study therefore investigated the biological processes linking ADHF and AKI with the aim of determining whether the plasma markers of endothelial injury and activation are associated with AKI in patients with ADHF. The study prospectively recruited 125 consecutive patients admitted to a coronary critical unit due to ADHF. Patients with and without AKI were compared in terms of soluble thrombomodulin (sTM), angiopoietin (Ang)-1 and -2 plasma levels as well as baseline characteristics. Among the study population, 14 (11.2%) patients developed CRS within 7 days after admission. The hemoglobin levels (median [IQR]11.3[10.8-12.6] vs. 13.5 [12.2-15.0] g/dL,

Indexed as

Acute Kidney InjuryHeart FailureBiomarkersHumansRisk FactorsThrombomodulinBiomarkersThrombomodulinCardiorenal syndromeendothelial dysfunctionheart failurekidney injury

Identifiers

PMID36354140
PMCPMC9704091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.