SynthesisPsychiatric genetics2022
Applications of Mendelian randomization in psychiatry: a comprehensive systematic review.
Synthesis in Psychiatric genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Causal validation of the relationship between 35 blood and urine biomarkers and hyperthyroidism: a bidirectional Mendelian randomization study and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls.Molecular psychiatry · 2026Article
- Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies.EClinicalMedicine · 2025Article
- Biomarkers of bipolar disorder in omics and neuroimaging.Journal of pharmaceutical analysis · 2025Review
- Review
- Bayesian causal graphical model for joint Mendelian randomization analysis of multiple exposures and outcomes.American journal of human genetics · 2025Article
- Mendelian randomization analysis reveals causal relationship between depression, antidepressants and benign paroxysmal vertigo.Scientific reports · 2025Article
- Testing the causal relationship of fat and sugar intake with depression and cortisol: a Mendelian Randomisation study.Translational psychiatry · 2024Article
- Schizophrenia genomics: genetic complexity and functional insights.Nature reviews. Neuroscience · 2024Review
- Assessing the Role of Cortisol in Anxiety, Major Depression, and Neuroticism: A Mendelian Randomization Study UsingBiological psychiatry global open science · 2024Article
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes.Translational psychiatry · 2024Article
- Association among attention-deficit hyperactivity disorder, restless legs syndrome, and peripheral iron status: a two-sample Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study.Frontiers in psychiatry · 2024Article
- Borderline personality disorder and risk of atrial fibrillation: insights from a bidirectional Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review.Consortium psychiatricum · 2024Article
- Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review.Frontiers in psychiatry · 2024Review
- Monoclonal antibody precision therapy targeting inflammation for bipolar disorder: a narrative review.Therapeutic advances in psychopharmacology · 2024Review
- Association between hs-CRP and depressive symptoms: a cross-sectional study.Frontiers in psychiatry · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Effects of Exercise on Functional Recovery in Patients with Bipolar Depression: A Study Protocol for a Randomized Controlled Trial.Metabolites · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify their risk factors and causative mechanisms due to their multifactorial nature, the limited physiopathological insight, the many confounding factors, and the potential reverse causality between the risk factors and psychiatric diseases. These characteristics make Mendelian randomization (MR) a precious tool for studying these disorders. MR is an analytical method that employs genetic variants linked to a certain risk factor, to assess if an observational association between that risk factor and a health outcome is compatible with a causal relationship. We report the first systematic review of all existing applications and findings of MR in psychiatric disorders, aiming at facilitating the identification of risk factors that may be common to different psychiatric diseases, and paving the way to transdiagnostic MR studies in psychiatry, which are currently lacking. We searched Web of Knowledge, Scopus, and Pubmed databases (until 3 May 2022) for articles on MR in psychiatry. The protocol was preregistered in PROSPERO (CRD42021285647). We included methodological details and results from 50 articles, mainly on schizophrenia, major depression, autism spectrum disorders, and bipolar disorder. While this review shows how MR can offer unique opportunities for unraveling causal links in risk factors and etiological elements of specific psychiatric diseases and transdiagnostically, some methodological flaws in the existing literature limit reliability of results and probably underlie their heterogeneity. We highlight perspectives and recommendations for future works on MR in psychiatry.
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