ReviewThe Lancet. Neurology2023
Tourette syndrome: clinical features, pathophysiology, and treatment.
Review in The Lancet. Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06889480 (MultitArget STereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome), which is not on this map. Cited by 115 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MultitArget STereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome
Who cites it
115 citing papers in PubMed, 6 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Application of acupuncture and moxibustion for tic disorders: An overview of systematic reviews and meta-analysis.Medicine · 2025Pooled it
- Global bibliometric analysis of Tourette syndrome research (1960-2024): trends, collaborations and emerging themes.Frontiers in neurology · 2025Pooled it
- Dopamine in Tourette syndrome: a 30-year bibliometric analysis of hotspot evolution.Frontiers in neurology · 2025Pooled it
- Systematic review-understanding the barriers and facilitators experienced by healthcare professionals in providing care for tics: a mixed methods systematic review of clinical knowledge, attitudes, and practices.BMC medical education · 2024Pooled it
- Association between human herpesviruses infections and childhood neurodevelopmental disorders: insights from two-sample mendelian randomization analyses and systematic review with meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Biomarkers and Tourette syndrome: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Efficacy and Safety of Ecopipam for Tourette Syndrome: A Phase 3 Randomized Clinical Trial.JAMA neurology · 2026Trial
- Therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders: a pilot randomised controlled trial.European child & adolescent psychiatry · 2026Trial
- Safety and Effect of 12-Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome.Movement disorders clinical practice · 2025Trial
- Effects of acupuncture combined with bone-setting therapy to treat tourette syndrome: a three-arm randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Risky Impulsive Behavior in Gilles de la Tourette Syndrome.Journal of clinical medicine · 2026Article
- Aberrant brain functional connectivity is associated with clinical symptoms in tourette syndrome: a triple network model perspective.European child & adolescent psychiatry · 2026Article
- Explosive Outbursts in Children With Tourette Syndrome: A Closer Look at Family Functioning Dimensions.Child psychiatry and human development · 2026Article
- Article
- Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes.Nature neuroscience · 2026Article
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- Parietal signatures of urge control in paediatric tic disorders: Hyperactivation and salience-biased coupling.European child & adolescent psychiatry · 2026Article
- MindTS-MMD: A Chinese Multimodal Dataset for Emotion Expression Analysis in Children with Tourette Syndrome.Scientific data · 2026Article
- Care pathways for tourette syndrome are deficient: implementing a stepped, needs-based approach.European child & adolescent psychiatry · 2026Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Tourette syndrome is a chronic neurodevelopmental disorder characterised by motor and phonic tics that can substantially diminish the quality of life of affected individuals. Evaluating and treating Tourette syndrome is complex, in part due to the heterogeneity of symptoms and comorbidities between individuals. The underlying pathophysiology of Tourette syndrome is not fully understood, but recent research in the past 5 years has brought new insights into the genetic variations and the alterations in neurophysiology and brain networks contributing to its pathogenesis. Treatment options for Tourette syndrome are expanding with novel pharmacological therapies and increased use of deep brain stimulation for patients with symptoms that are refractory to pharmacological or behavioural treatments. Potential predictors of patient responses to therapies for Tourette syndrome, such as specific networks modulated during deep brain stimulation, can guide clinical decisions. Multicentre data sharing initiatives have enabled several advances in our understanding of the genetics and pathophysiology of Tourette syndrome and will be crucial for future large-scale research and in refining effective treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.