Evidence map›Paper›PMID 36353986›Full record

ArticleNucleic acids research2023

COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas.

Dapeng Wang, Vinod Kumar, Katie L Burnham, Alexander J Mentzer, Brian D Marsden, Julian C Knight

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dapeng WangWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-9925-4574
Vinod KumarKennedy Institute for Rheumatology, University of Oxford, UK.
Katie L BurnhamWellcome Sanger Institute, Cambridge, UK.
Alexander J MentzerWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-4502-2209
Brian D MarsdenKennedy Institute for Rheumatology, University of Oxford, UK.
Julian C KnightWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-0377-5536
Centre for Human Genetics · GBUniversity of Oxford · GBWellcome Sanger Institute · GB

Funding

Department of HealthMedical Research Council MR/V002503/1Wellcome Trust 206194
6 · The paper itself

Abstract

Advances in our understanding of the nature of the immune response to SARS-CoV-2 infection, and how this varies within and between individuals, is important in efforts to develop targeted therapies and precision medicine approaches. Here we present a database for the COvid-19 Multi-omics Blood ATlas (COMBAT) project, COMBATdb (https://db.combat.ox.ac.uk). This enables exploration of multi-modal datasets arising from profiling of patients with different severities of illness admitted to hospital in the first phase of the pandemic in the UK prior to vaccination, compared with community cases, healthy controls, and patients with all-cause sepsis and influenza. These data include whole blood transcriptomics, plasma proteomics, epigenomics, single-cell multi-omics, immune repertoire sequencing, flow and mass cytometry, and cohort metadata. COMBATdb provides access to the processed data in a well-defined framework of samples, cell types and genes/proteins that allows exploration across the assayed modalities, with functionality including browse, search, download, calculation and visualisation via shiny apps. This advances the ability of users to leverage COMBAT datasets to understand the pathogenesis of COVID-19, and the nature of specific and shared features with other infectious diseases.

Indexed as

COVID-19Databases, FactualHumansMultiomicsProteomicsSARS-CoV-2

Identifiers

PMID36353986
PMCPMC9825482
OpenAlexW4308682319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.