ArticleJournal of cachexia, sarcopenia and muscle2023
Grip strength is inversely associated with DNA methylation age acceleration.
Article in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States.GeroScience · 2026Article
- Association of biological age acceleration with muscle aging phenotype in young and middle-aged adults: a prospective cohort study.GeroScience · 2026Article
- Review
- Grip strength indicators and successful aging among middle-aged and older adults: evidence from the CHARLS cohort.Scientific reports · 2026Article
- Calorie Restriction Effects on Aging, Learning Performance, and Transcription in Aged Aplysia californica.Genes, brain, and behavior · 2026Article
- Sarcopenia and Muscle Aging: Updated Insights into Molecular Mechanisms and Translational Therapeutics.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- Accelerated biological aging and risk of sarcopenia: evidence from 29,000 Chinese adults.Biology of sport · 2026Article
- Age-related changes in hand function - it's not just about muscle strength.Frontiers in human neuroscience · 2026Review
- CD21Frontiers in aging · 2026Article
- Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI Cohort.medRxiv : the preprint server for health sciences · 2025Article
- What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025Review
- Cumulative neighborhood disadvantage and racial and geographic disparities in epigenetic aging.SSM - population health · 2025Article
- Use of Technology in the Rehabilitation Setting: Therapy Observations, Mixed Methods Analysis, and Data Visualization.Archives of rehabilitation research and clinical translation · 2025Article
- The mediating effect of handgrip strength on the association between sleep duration and basal metabolic rate in middle-aged and older adults: evidence from the China health and retirement longitudinal study.Frontiers in public health · 2025Article
- Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues.Frontiers in aging · 2025Article
- Adult Physical Function Has Roots in Early Childhood Brain Function: A Five-Decade Cohort Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Mediation role of DNA methylation in association between handgrip strength and cognitive function in monozygotic twins.Journal of human genetics · 2024Article
- The effect of low birth weight as an intrauterine exposure on the early onset of sarcopenia through possible molecular pathways.Journal of cachexia, sarcopenia and muscle · 2024Review
- The Grip Strength Loss Rate and the Subsequent Cognitive Decline Rate in Older Adults: The Moderating Role of Social Isolation.Innovation in aging · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThere is a large body of evidence linking muscular weakness, as determined by low grip strength, to a host of negative ageing-related health outcomes. Given these links, grip strength has been labelled a 'biomarker of aging'; and yet, the pathways connecting grip strength to negative health consequences are unclear. The objective of this study was to determine whether grip strength was associated with measures of DNA methylation (DNAm) age acceleration.
methodsMiddle age and older adults from the 2006 to 2008 waves of the Health and Retirement Study with 8-10 years of follow-up were included. Cross-sectional and longitudinal regression modelling was performed to examine the association between normalized grip strength (NGS) and three measures of DNAm age acceleration, adjusting for cell composition, sociodemographic variables and smoking. Longitudinal modelling was also completed to examine the association between change in absolute grip strength and DNAm age acceleration. The three DNAm clocks used for estimating age acceleration include the established DunedinPoAm, PhenoAge and GrimAge clocks.
resultsThere was a robust and independent cross-sectional association between NGS and DNAm age acceleration for men using the DunedinPoAm (β: -0.36; P < 0.001), PhenoAge (β: -8.27; P = 0.01) and GrimAge (β: -4.56; P = 0.01) clocks and for women using the DunedinPoAm (β: -0.36; P < 0.001) and GrimAge (β: -4.46; P = 0.01) clocks. There was also an independent longitudinal association between baseline NGS and DNAm age acceleration for men (β: -0.26; P < 0.001) and women (β: -0.36; P < 0.001) using the DunedinPoAm clock and for women only using the PhenoAge (β: -8.20; P < 0.001) and GrimAge (β: -5.91; P < 0.001) clocks. Longitudinal modelling revealed a robust association between change in grip strength from wave 1 to wave 3 was independently associated with PhenoAgeAA (β: -0.13; 95% CI: -0.23, -0.03) and GrimAgeAA (β: -0.07; 95% CI: -0.14, -0.01) in men only (both P < 0.05).
conclusionsOur findings provide some initial evidence of age acceleration among men and women with lower NGS and loss of strength over time. Future research is needed to understand the extent to which DNAm age mediates the association between grip strength and chronic disease, disability and mortality.
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