ArticleFrontiers in molecular biosciences2022
SpiDec: Computing binodals and interfacial tension of biomolecular condensates from simulations of spinodal decomposition.
Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 10 citations in OpenAlex.
- Backbone Hydrogen Bonding as a Determinant of Condensate Material States.Journal of the American Chemical Society · 2026Article
- Atomistic molecular dynamics simulations of intrinsically disordered proteins.Current opinion in structural biology · 2025Review
- Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates.Cell reports. Physical science · 2024Article
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
- Amino Acid-Dependent Material Properties of Tetrapeptide Condensates.bioRxiv : the preprint server for biology · 2024Article
- Phase separation of multicomponent peptide mixtures into dehydrated clusters with hydrophilic cores.Biophysical journal · 2024Article
- Adenosine Triphosphate Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks.Journal of the American Chemical Society · 2024Article
- ATP Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks.bioRxiv : the preprint server for biology · 2023Article
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3 authors at 1 institution in 1 country.
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Abstract
Phase separation of intrinsically disordered proteins (IDPs) is a phenomenon associated with many essential cellular processes, but a robust method to compute the binodal from molecular dynamics simulations of IDPs modeled at the all-atom level in explicit solvent is still elusive, due to the difficulty in preparing a suitable initial dense configuration and in achieving phase equilibration. Here we present SpiDec as such a method, based on spontaneous phase separation
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