ArticleNature synthesis2022
Enantiodivergent epoxidation of alkenes with a photoswitchable phosphate manganese-salen complex.
Article in Nature synthesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Controlling the rotary direction of light-driven molecular motors by topological confinement.Chemical science · 2026Article
- Artificial Processive Catalytic Systems: Bridging Synthetic Polymers and Biological Precision.Polymer science & technology (Washington, D.C.) · 2025Article
- Design Approaches That Utilize Ionic Interactions to Control Selectivity in Transition Metal Catalysis.Chemical reviews · 2025Review
- General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light.Science advances · 2025Article
- Switchable supramolecular helices for asymmetric stereodivergent catalysis.Nature communications · 2024Article
- Enlightening dynamic functions in molecular systems by intrinsically chiral light-driven molecular motors.Chemical Society reviews · 2023Review
- Designing P-type bi-stable overcrowded alkene-based chiroptical photoswitches.Chemical science · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The development of enantiodivergent catalysts capable of preparing both enantiomeric products from one substrate in a controlled fashion is challenging. Introducing a switching function into the catalyst can address this challenge, allowing the chiral reaction environment to reversibly change during catalysis. Here we report a photoswitchable phosphate ligand, derived from 2,2'-biphenol, which axially coordinates as the counter ion to an achiral manganese(III) salen catalyst, providing the latter with the ability to switch stereoselectivity in the epoxidation of alkenes. The enantiomers of the chiral ligand exist as a pair of pseudo-enantiomers, which can be interconverted by irradiation with light of different wavelengths. The opposite axial chirality of these pseudo-enantiomers is efficiently transferred to the manganese(III) salen catalyst. With this switchable supramolecular catalyst, the enantioselectivity of the epoxidation of a variety of alkenes can be controlled, resulting in opposite enantiomeric excesses of the epoxide products. This transfer of chirality from a photoswitchable anionic ligand to a metal complex broadens the scope of supramolecular catalysts.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.