ArticleFrontiers in oncology2022
Quality of life and function after rectal cancer surgery with and without sphincter preservation.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of a Mobile Health-Based Remote Interaction Management Intervention on the Quality of Life and Self-Management Behavior of Patients With Low Anterior Resection Syndrome: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Development and formative evaluation of a follow-up checklist for patients who have undergone sphincter-preserving surgery for rectal cancer based on the Supportive Care Framework.Asia-Pacific journal of oncology nursing · 2026Article
- Article
- Quality of Life and Functional Outcomes After Rectal Cancer Surgery: A Comparative Study Applying EORTC QLQ-C30, QLQ-CR29, and LARS Score at 1-6 Months Postoperatively.Healthcare (Basel, Switzerland) · 2026Article
- Low anterior resection syndrome after sphincter-preserving surgery for rectal cancer: predictive factors and impact on perceived functional satisfaction.Discover oncology · 2026Article
- Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.Frontiers in oncology · 2026Article
- Risk of Residual Cancer following Immediate Surgery or Nonoperative Management after Malignant Colorectal Polypectomy with High-Risk Features.JCO oncology advances · 2025Article
- Article
- Practice of quality management for dental handpiece processing based on FOCUS-PDCA programme.BMC oral health · 2025Observational
- Watch-and-wait approach in high-risk locally advanced rectal cancer: outcomes after complete response to total neoadjuvant therapy.BJS open · 2025Article
- Patient-Reported Outcomes After Neoadjuvant Therapy and Watch-and-Wait for Rectal Cancer: A Systematic Review and Meta-Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- From Diversion to Permanence: Trends in Ostomy Creation in Rectal Cancer Surgery.Journal of clinical medicine · 2025Review
- Cost-Effectiveness of Total Neoadjuvant Therapy With Selective Nonoperative Management for Locally Advanced Rectal Cancer: Analysis of Data From the Organ Preservation for Rectal Adenocarcinoma Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Robotic-assisted colorectal surgery in colorectal cancer management: a narrative review of clinical efficacy and multidisciplinary integration.Frontiers in oncology · 2025Review
- Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery.Scientific reports · 2024Article
- The bowel function instrument for rectal cancer survivors with anastomosis and ostomy.Journal of psychosomatic research · 2024Article
- Article
- Course and predictors of supportive care needs among colorectal cancer survivors with ostomies: a longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients.International journal of colorectal disease · 2023Article
- A practical review of watch-and-wait approach in rectal cancer.Radiation oncology journal · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Despite improvements in surgical techniques, functional outcomes and quality of life after therapy for rectal cancer remain suboptimal. We sought to prospectively evaluate the effect of bowel, bladder, and sexual functional outcomes on health-related quality of life (QOL) in patients with restorative versus non-restorative resections after rectal cancer surgery. A cohort of 211 patients with clinical stage I-III rectal cancer who underwent open surgery between 2006 and 2009 at Memorial Sloan Kettering were included. Subjects were asked to complete surveys preoperatively and at 6, 12, and 24 months after surgery. Validated instruments were used to measure QOL, bowel, bladder, and sexual function. Univariable and multivariable regression analyses evaluated predictors of 24- month QOL. In addition, longitudinal trends over the study period were evaluated using repeated measures models. In total, 180 patients (85%) completed at least 1 survey, and response rates at each time point were high (>70%). QOL was most impaired at 6 and 12 months and returned to baseline levels at 24 months. Among patients who underwent sphincter-preserving surgery (SPS; n=153 [85%]), overall bowel function at 24 months was significantly impaired and never returned to baseline. There were no differences in QOL at 24 months between patients who underwent SPS and those who did not (p=.29). Bowel function was correlated with QOL at 24 months (Pearson correlation,.41; p<.001). QOL among patients who have undergone SPS for rectal cancer is good despite poor function. Patients with ostomies are able to adjust to the functional changes and, overall, have good global QOL. Patients with low anastomoses had lower global QOL at 24 months than patients with permanent stomas. Our findings can help patients set expectations about function and quality of life after surgery for rectal cancer with and without a permanent stoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.