ArticleFrontiers in public health2022
Case series: Diquat poisoning with acute kidney failure, myocardial damage, and rhabdomyolysis.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 36 citations in OpenAlex.
- Case report: Successful rescue of an adult patient with diquat poisoning complicated by rhabdomyolysis and compartment syndrome.International journal of emergency medicine · 2026Article
- Development and validation of a bedside prognostic model for in-hospital mortality in acute diquat poisoning.BMC emergency medicine · 2026Article
- Acute diquat poisoning in children: a single-center retrospective observational study.Frontiers in pediatrics · 2026Article
- Tannic acid inhibits diquat induced human renal HK-2 cells apoptosis through BAX/Bcl2/caspase/cleaved caspase-3 signaling pathway.Biomedical engineering online · 2025Article
- Molecular mechanisms in diquat-induced organs injury：insights into cell signaling and potential therapeutic agents.Cell biology and toxicology · 2025Review
- Diquat Induces Cell Death and dopamine Neuron Loss via Reactive Oxygen Species Generation inEnvironmental science & technology · 2025Article
- Case report: A case of acute renal failure, rhabdomyolysis, and toxic encephalopathy associated with diquat poisoning in a pregnant woman.Frontiers in medicine · 2025Article
- Case Report: A rare case of acute herbicide poisoning induced pediatric acute osteofascial compartment syndrome.Frontiers in pediatrics · 2025Article
- Diquat poisoning, maybe another cause of osmotic demyelination syndrome: case report and literature review.Frontiers in medicine · 2025Article
- Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies.Frontiers in pharmacology · 2025Review
- Early Immune-Inflammatory Profiling and Prognostic Biomarkers in Patients with Acute Diquat Poisoning: A Multicenter Study with Exploratory Bioinformatics Analysis.Journal of inflammation research · 2025Article
- Interpretable machine learning for the prediction of death risk in patients with acute diquat poisoning.Scientific reports · 2024Article
- Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning.Cell death and differentiation · 2024Article
- Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury.Kidney international reports · 2024Article
- Elucidating the mechanisms underlying astrocyte-microglia crosstalk in hippocampal neuroinflammation induced by acute diquat exposure.Environmental science and pollution research international · 2024Article
- Chlorfenapyr-related delayed rhabdomyolysis: a case series.Frontiers in neurology · 2024Article
- Assessment of rehabilitation treatment for patients with acute poisoning-induced toxic encephalopathy.World journal of emergency medicine · 2024Article
- Investigating Clinical Factors Influencing Pulmonary Fibrosis in Acute Diquat Poisoning.International journal of general medicine · 2024Article
- The impact of dietary supplementation of Quercetagetin on growth, antioxidant capacity, and gut microbiota of diquat-challenged broilers.Frontiers in microbiology · 2024Article
- Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway.Frontiers in pharmacology · 2024Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diquat is a herbicide that can have deleterious effects on the kidneys, liver, heart, lungs, and central nervous system on ingestion. Diquat poisoning-associated rhabdomyolysis has rarely been reported. We describe two cases of diquat poisoning with acute renal failure, myocardial damage, and rhabdomyolysis. Case 1: A 17-year-old man experienced anuria after ingesting ~200 mL of diquat 16 h prior. On admission, his creatinine (400 μmol/L), urea (11.7 mmol/L), creatine kinase (2,534 IU/L), and myohemoglobin (4,425 ng/mL) concentrations were elevated. Case 2: An 18-year-old woman who ingested ~200 mL of diquat 5.5 h prior to admission had normal creatinine, urea, and creatine kinase concentrations. Eleven hours after ingestion, she developed anuria with elevated creatinine (169 μmol/L) concentration; her creatine kinase (13,617 IU/L) and myohemoglobin (>3,811 ng/mL) concentrations were remarkably elevated 24 h after ingestion. Both patients also had elevated aminotransferase and myocardial enzyme concentrations. After undergoing hemoperfusion and hemofiltration, blood diquat concentrations in cases 1 and 2 on admission (16/6 h after ingestion), after hemoperfusion (20/11 h after ingestion), and after 8 h of hemofiltration/8 h of hemofiltration and 2 h of hemoperfusion (29/21 h after ingestion) were 4.9/9.1, 3.4/5.4, and 1.5/1.2 μg/mL, respectively. Severe diquat poisoning can cause acute kidney failure and rhabdomyolysis. Rhabdomyolysis may induce myocardial injury, aggravating kidney damage, and also increase transaminase concentration. Hemoperfusion and hemofiltration could be effective treatments for eliminating diquat in the blood.
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