Evidence map›Paper›PMID 36352998›Full record

ArticleJournal of family medicine and primary care2022

Association of -675 4G/5G PAI-1 and -2518A/G MCP-1 genetic polymorphisms with polycystic ovary syndrome in Kashmiri women: A case control study.

Syed Douhath Yousuf, Mohammad Ashraf Ganie, Syed Mudassar, Humiara Shafi, Saima Ibrahim, Humira Jeelani, Gowhar Rashid, Mohammad A Zargar, Fouzia Rashid

Open access · goldAbstract read
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In one paragraph

Article in Journal of family medicine and primary care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Syed Douhath YousufDepartment of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Jammu and Kashmir, India.
Mohammad Ashraf GanieDepartment of Endocinology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Jammu and Kashmir, India.
Syed MudassarDepartment of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Jammu and Kashmir, India.
Humiara ShafiDepartment of Clinical Biochemistry, University of Kashmir, Jammu and Kashmir, India.
Saima IbrahimDepartment of Clinical Biochemistry, University of Kashmir, Jammu and Kashmir, India.
Humira JeelaniAdvanced Centre for Human Genetics, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Jammu and Kashmir, India.
Gowhar RashidDepartment of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Jammu and Kashmir, India.
Mohammad A ZargarDepartment of Biotechnology, Nuner Campus, Central University of Kashmir, Jammu and Kashmir, India.
Fouzia RashidDepartment of Clinical Biochemistry, University of Kashmir, Jammu and Kashmir, India.
Sher-i-Kashmir Institute of Medical Sciences · INUniversity of Kashmir · INCentral University of Kashmir · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a highly prevalent endocrine disorder among females of fertile age. It has been speculated to be associated with low-grade chronic inflammation like other inflammatory response-driven multifactorial illnesses such as diabetes mellitus (DM) and cancer. Monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) are biomarkers of inflammation and endothelial dysfunction, respectively. These have been found to be elevated in PCOS patients. The current research reveals that single nucleotide polymorphisms (SNPs) in their genes are strongly associated with the elevation of these biomarkers. The goal of this study was to see if there was a link between PAI-1 -675 4G/5G and MCP-1 -2518 A/G polymorphisms with the occurrence of PCOS. Material and Method: This study included 220 PCOS participants and 220 healthy controls. The allele-specific polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods were used to investigate PAI-1-675 4G/5G and MCP-1 -2518A/G SNPs, respectively. Results: The -675 4G/5G SNP in the PAI-1 gene was strongly linked to PCOS. The odds ratio (OR) for the 4G/4G genotype was (OR = 3.2; Conclusion: Both PAI-1 -675 4G/5G and MCP-1 -2518A/G polymorphisms are associated with predisposition to PCOS and its complications in Kashmiri women.

Indexed as

Coagulationinflammationmonocyte chemoattractant protein-1plasminogen activator inhibitor-1polycystic ovary syndromepolymorphism

Identifiers

PMID36352998
PMCPMC9638670
OpenAlexW4295345777

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.