Evidence map›Paper›PMID 36352931›Full record

ArticleJournal of family medicine and primary care2022

CoRe study: COVID-19 and remdesivir: An insight into the current health planning and policy.

M M Samim, Debjyoti Dhar, Vikram Singh, B S Nagaraja, M S Shahyan, Treshita Dey, Naznin Parvin, Debayan Dutta, Rutul D Shah, M Bhavesh and 8 more

Open access · goldAbstract read
In one paragraph

Article in Journal of family medicine and primary care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 1 country.

M M SamimDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Debjyoti DharDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Vikram SinghDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
B S NagarajaDepartment of Internal Medicine, Bowring and Lady Curzon Hospital, Bengaluru, Karnataka, India.
M S ShahyanNeuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Treshita DeyDepartment of Radiation Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Naznin ParvinDepartment of Pediatrics, Lady Hardinge Medical College and Hospital, New Delhi, India.
Debayan DuttaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Rutul D ShahDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
M BhaveshDepartment of General Medicine, All India Institute of Medical Sciences, New Delhi, India.
Sheeetal GoyalDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Mallesh KariyappaDepartment of Pediatrics, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
Subhrakamal SahaDepartment of General Medicine, Jawaharlal Nehru Hospital & Research Centre, Sector-9, Hospital Sector, Bhilai, Chhattisgarh, India.
Preetam GoswamiDepartment of Pulmonary Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.
Debarup DasDepartment of General Medicine, Medical College Hospital, Kolkata, West Bengal, India.
Shivani ShahDepartment of General Medicine, BJMC & Civil Hospital, Ahmedabad, Gujarat, India.
K N RameshDepartment of General Medicine, Fortis Hospital, Cunningham Road, Bengaluru, Karnataka, India.
Jaipuriar ShekharDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
National Institute of Mental Health and Neurosciences · INAll India Institute of Medical Sciences · INBangalore Medical College and Research Institute · INB.J. Medical College · INBurdwan Medical College & Hospital · INFortis Hospital · INJawaharlal Nehru Cancer Hospital and Research Centre · INLady Hardinge Medical College · INMedical College and Hospital, Kolkata · INPost Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The ongoing coronavirus disease-2019 (COVID-19) pandemic has witnessed rampant use of the repurposed drug, remdesivir, despite its conflicting evidence and rapidly changing guidelines. Methods: A cross-sectional, country-wide, questionnaire-based, electronic survey was conducted among the healthcare professionals involved in COVID-19 management from April 18 to May 18, 2021. Results: Out of 231 responses, 185 were included. Significantly, greater knowledge of trials was reported by the frontline healthcare professionals compared to those who are not involved in COVID-19 care. Medicine practitioners and pulmonologists expressed greater willingness to continue remdesivir (Odds ratio (OR) 5.329, 95% Confidence interval (CI) 2.31-12.291 and 5.063, 95% CI 1.414-18.129, respectively). The rationale attributed was personal experience, current guidelines, non-availability of any alternate antiviral drug, expert recommendations, and local hospital policy either alone (20%, 8.1%, 5.9%, 2.7%, and 2.2%, respectively) or in combination (46.5%, 39.5%, 29.2%, 21.1%, and 15.7%, respectively). Awareness of evidence and knowledge of landmark studies made no statistically significant impact on clinical decision-making. Improved clinical outcomes were reported by 10/22 (45.4%) practitioners who used remdesivir for unconventional indications. Conclusion: The study throws critical insights into the current perspectives of doctors on remdesivir in clinical management and its potential impact on current health planning strategies.

Indexed as

COVID-19evidence-based medicineguidelineremdesivir

Identifiers

PMID36352931
PMCPMC9638552
OpenAlexW4295345965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.