ArticleFrontiers in cardiovascular medicine2022
Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 64 citations in OpenAlex.
- Mediating role of telomere shortening in dioxin-like polychlorinated biphenyls associated cognitive decline in children.Environmental health : a global access science source · 2026Article
- The effect of micronutrient levels on leukocyte telomere length: A Mendelian randomization study.Medicine · 2026Article
- Review
- Relative Leukocyte Telomere Length Is Associated with Multimorbidity Burden in Older Adults: Evidence for Sex-Specific Associations.International journal of molecular sciences · 2026Article
- Determinants of chromosome-specific telomere lengths among 2573 All of Us participants.Nature communications · 2026Article
- The Impact of Weight Loss Secondary to Bariatric Surgery on Telomere Biology: A Narrative Review.Biomedicines · 2026Review
- Leukocyte telomere length and circulating MiRNAs in relation to cardiovascular outcomes in older adults.BMC geriatrics · 2026Article
- Effect of physical activity on telomere length among middle-aged Indian adults: A cross-sectional study.Bioinformation · 2026Article
- Aging and coronary artery calcification: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis.Nature communications · 2025Article
- Targeting Telomere Shortening in Vascular Aging and Atherosclerosis: Therapeutic Promise ofJournal of cardiovascular development and disease · 2025Review
- Relationship between cellular aging, perceived stress, and cardiometabolic disease risk in Black family caregivers of persons with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Causal relationships between leukocyte telomere length and female reproductive system diseases: a bidirectional Mendelian randomization study.Reproductive and developmental medicine · 2025Article
- Causal analysis of 731 immunophenotypes and heart failure: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Telomere Length as Both Cause and Consequence in Type 1 Diabetes: Evidence from Bidirectional Mendelian Randomization.Biomedicines · 2025Article
- The relationship between telomere length and aging-related diseases.Clinical and experimental medicine · 2025Review
- Telomere length as a biomarker for fetal fraction prediction in non-invasive prenatal testing.PloS one · 2025Article
- Glaucoma and cardiovascular disease: a bidirectional two-sample Mendelian randomization analysis.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Micronutrient intake and telomere length: findings from the UK Biobank.European journal of nutrition · 2024Article
- Causal association between cystatin C and diabetic retinopathy: A two-sample Mendelian randomization study.Journal of diabetes investigation · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Background: The causal direction and magnitude of the associations between telomere length (TL) and cardiovascular diseases (CVDs) remain uncertain due to susceptibility of reverse causation and confounding. This study aimed to investigate the associations between TL and CVDs using Mendelian randomization (MR). Materials and methods: In this two-sample MR study, we identified 154 independent TL-associated genetic variants from a genome-wide association study (GWAS) consisting of 472,174 individuals (aged 40-69) in the UK Biobank. Summary level data of CVDs were obtained from different GWASs datasets. Methods of inverse variance weighted (IVW), Mendelian Randomization-Egger (MR-Egger), Mendelian Randomization robust adjusted profile score (MR-RAPS), maximum likelihood estimation, weighted mode, penalized weighted mode methods, and Mendelian randomization pleiotropy residual sum and outlier test (MR-PRESSO) were conducted to investigate the associations between TL and CVDs. Results: Our findings indicated that longer TL was significantly associated with decreased risk of coronary atherosclerosis [odds ratio (OR), 0.85; 95% confidence interval (CI), 0.75-0.95; Conclusion: Our MR study suggested that longer telomeres were associated with decreased risk of several CVDs, including coronary atherosclerosis, myocardial infarction, ischemic heart disease, and stroke, as well as an increased risk of hypertension. Future studies are still warranted to validate the results and investigate the mechanisms underlying these associations.
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