ArticlePlant communications2023
Orthologous genes Pm12 and Pm21 from two wild relatives of wheat show evolutionary conservation but divergent powdery mildew resistance.
Article in Plant communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Agronomic Performance and Dual Resistance Evaluation to Powdery Mildew and Stripe Rust in 660 Wheat Germplasm Lines.Plants (Basel, Switzerland) · 2026Article
- Recent physiological, genetic, and management perspectives on lodging resistance in rice.Planta · 2026Review
- Dynamics of H3K4me3 and H3K36me3 histone modifications in response to powdery mildew infection in common wheat.BMC plant biology · 2026Article
- Current Status and Future Direction of the High-Temperature Resistance in Wheat to Control Stripe Rust.Molecular plant pathology · 2025Review
- Characterization and genetic dissection of the powdery mildew resistance in cultivated emmer wheat accession L424.BMC plant biology · 2025Article
- An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat.Nature communications · 2025Article
- Harnessing primary, secondary and tertiary genepools for durable wheat disease resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Paired NLRs originated from Triticum dicoccoides coordinately confer resistance to powdery mildew in wheat.Nature communications · 2025Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- Genetic Basis Identification of aPlants (Basel, Switzerland) · 2025Article
- Homoeologous recombination-based transfer and cytological mapping of the novel powdery mildew resistance gene Pm7C from Aegilops caudata.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Development and application of a cost-effective multiplex Kompetitive Allele-Specific polymerase chain reaction assay for pyramiding resistant genes of fusarium head blight and powdery mildew in wheat.BMC plant biology · 2025Article
- An NLR receptor confers broad-spectrum resistance to diversified powdery mildew sublineages in wheat and barley.Plant biotechnology journal · 2025Article
- Fine mapping ofMolecular breeding : new strategies in plant improvement · 2025Article
- An atypical NLR pair TdCNL1/TdCNL5 from wild emmer confers powdery mildew resistance in wheat.Nature genetics · 2025Article
- The wheat NLR pair RXL/Pm5e confers resistance to powdery mildew.Plant biotechnology journal · 2025Article
- Utilization of theMolecular breeding : new strategies in plant improvement · 2024Review
- An integrated pipeline facilitates fast cloning of a new powdery mildew resistance gene from the wheat wild relative Aegilops umbellulata.Plant communications · 2024Article
- An Aegilops longissima NLR protein with integrated CC-BED module mediates resistance to wheat powdery mildew.Nature communications · 2024Article
- A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew.Nature communications · 2024Article
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wheat powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a devastating disease that threatens wheat production worldwide. Pm12, which originated from Aegilops speltoides, a wild relative of wheat, confers strong resistance to powdery mildew and therefore has potential use in wheat breeding. Using susceptible mutants induced by gamma irradiation, we physically mapped and isolated Pm12 and showed it to be orthologous to Pm21 from Dasypyrum villosum, also a wild relative of wheat. The resistance function of Pm12 was validated via ethyl methanesulfonate mutagenesis, virus-induced gene silencing, and stable genetic transformation. Evolutionary analysis indicates that the Pm12/Pm21 loci in wheat species are relatively conserved but dynamic. Here, we demonstrated that the two orthologous genes, Pm12 and Pm21, possess differential resistance against the same set of Bgt isolates. Overexpression of the coiled-coil domains of both PM12 and PM21 induces cell death in Nicotiana benthamiana leaves. However, their full-length forms display different cell death-inducing activities caused by their distinct intramolecular interactions. Cloning of Pm12 will facilitate its application in wheat breeding programs. This study also gives new insight into two orthologous resistance genes, Pm12 and Pm21, which show different race specificities and intramolecular interaction patterns.
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