ArticleBMC chemistry2022
Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model.
Article in BMC chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Doxorubicin-loaded gold nanoparticles for enhanced anticancer efficacy: in vitro, in vivo, and FTIR-based tissue analysis.Scientific reports · 2026Article
- Colloidal Gold Dietary Supplements as Nanomaterials: Physicochemical Evaluation, Estimated Oral Exposure, and Preliminary Biological Assessment.International journal of molecular sciences · 2026Article
- Functionalized Core/Shell Gold-Palladium Bimetallic Nanoparticles in Transferrin-Targeted Dual-Drug Delivery in a Cervical Cancer Cell Model.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Biofabrication ofLife (Basel, Switzerland) · 2025Article
- Enhanced Stability of Multi-Functionalized Gold Nanoparticles and Potential Anticancer Efficacy on Human Cervical Cancer Cells.Biomedicines · 2025Article
- Multifunctional gold nanoparticles for cancer theranostics.3 Biotech · 2024Review
- Doxorubicin Incorporation into Gold Nanoparticles: An In Vivo Study of Its Effects on Cardiac Tissue in Rats.Nanomaterials (Basel, Switzerland) · 2024Article
- Review
- Laser enhanced photothermal effect of silver nanoparticles synthesized by chemical and green method on Gram-positive and Gram-negative bacteria.BMC chemistry · 2024Article
- In Vitro Toxicological Insights from the Biomedical Applications of Iron Carbide Nanoparticles in Tumor Theranostics: A Systematic Review and Meta-Analysis.Nanomaterials (Basel, Switzerland) · 2024Review
- Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models.BMC chemistry · 2024Article
- Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles.Pharmaceutics · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe difficulty of achieving targeted drug delivery following administration of presently marketed anticancer therapeutics is still a concern. Metallic nanoparticles (NPs) appear to be promising in this regard. The present study focused on the use of gold nanoparticles (AuNPs) as a drug carrier for anticancer Doxorubicin (DOX) forming DOX-AuNPs nanocomposite. The anticancer effect of the prepared nanocomposite was evaluated using SRP essay on breast cancer cell line (MCF7) for different incubation times (24 h,48, and72hr). The prepared DOX-AuNPs nanocomposite was investigated by UV-visible spectroscopy, TEM, fluorescence spectroscopy, and FTIR spectroscopy.
resultsOur results showed that the prepared AuNPs and DOX-AuNPs nanocomposite have spherical and small size10 ± 2 nm and 12 ± 2 nm respectively. The potential cytotoxicity of the DOX-AuNPs nanocomposite on the MCF7 cell line was significantly increased compared to free DOX. The 20 µM DOX- AuNPs nanocomposite produced a similar decrease in cell survival as 80 µM free DOX.
conclusionFuture work is in progress to investigate the positive effects of the prepared nanocomposite for chemo-photothermal combination treatment.
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