ArticlePerioperative medicine (London, England)2022
An algorithm based on the postoperative decrease of albumin (ΔAlb) to anticipate complications after liver surgery.
Article in Perioperative medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 5 citations in OpenAlex.
- Early prediction of severe morbidity after liver resection using serum albumin and ALBI-score in a mixed patient cohort.BMC surgery · 2026Article
- Preoperative and early postoperative albumin thresholds, rather than ΔAlb, predict severe complications after colorectal cancer surgery: a multifactorial model and nomogram.Frontiers in oncology · 2026Article
- Article
- The dynamics of perioperative serum albumin before and after total knee arthroplasty.Journal of orthopaedics · 2024Article
- Postoperative decrease in serum albumin as predictor of early acute periprosthetic infection after total knee arthroplasty.Journal of orthopaedic surgery and research · 2024Article
- Assessment of the Predictive Value of Preoperative Serum Albumin and Postoperative Albumin Drop (ΔAlb) for Complications after Pancreas Surgery: A Single-Center Cross-Sectional Study.Journal of clinical medicine · 2023Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
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Abstract
backgroundPerioperative decrease of albumin (ΔAlb) appeared as a promising predictor of complications after digestive surgery, but its role after liver surgery remains unclear. This study aimed to analyze whether and how ΔAlb can be used to predict complications after liver surgery.
methodsA bicentric retrospective analysis of patients undergoing liver surgery (2010-2016) was performed, following TRIPOD guidelines. The preoperative and postoperative difference of albumin was calculated on POD 0 and defined as ΔAlb. Patients with any missing variable were excluded. The primary endpoint was overall complications according to the Clavien classification. A multiparametric algorithm based on ΔAlb was generated to optimize prediction performance.
resultsA total of 110 patients were analyzed. At least one complication occurred in 66 (60%) patients. Patients with and without complication showed a ΔAlb of 15.8 vs. 9.5 g/L (p<0.001). Area under ROC curve (AUC) of ΔAlb was 0.75 (p<0.01.). The ΔAlb-based algorithm showed an AUC of 0.84 (p<0.01), significantly improving performance (p=0.03). Multivariable analysis identified ΔAlb as independent predictor of complications (HR, 1.12; 95% CI, 1.01-1.07; p = 0.002).
conclusionsΔAlb appeared as a promising predictor independently associated with the risk of complication after liver surgery. The study presents a novel decision-tree based on ΔAlb to anticipate complications.
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