Evidence map›Paper›PMID 36352453›Full record

ArticleParasites & vectors2022

A prospective cohort study of Plasmodium falciparum malaria in three sites of Western Kenya.

Benyl M Ondeto, Xiaoming Wang, Harrysone Atieli, Daibin Zhong, Guofa Zhou, Ming-Chieh Lee, Pauline Winnie Orondo, Kevin O Ochwedo, Collince J Omondi, Simon M Muriu and 5 more

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Benyl M OndetoDepartment of Biology, University of Nairobi, Nairobi, 00100, Kenya. muyomabo@gmail.com.
Xiaoming WangProgram in Public Health, College of Health Sciences, University of California at Irvine, Irvine, CA, 92697, USA.
Harrysone AtieliSub-Saharan Africa International Center of Excellence for Malaria Research, Tom Mboya University, Homa Bay, 40300, Kenya.
Daibin ZhongProgram in Public Health, College of Health Sciences, University of California at Irvine, Irvine, CA, 92697, USA.
Guofa ZhouProgram in Public Health, College of Health Sciences, University of California at Irvine, Irvine, CA, 92697, USA.
Ming-Chieh LeeProgram in Public Health, College of Health Sciences, University of California at Irvine, Irvine, CA, 92697, USA.
Pauline Winnie OrondoSub-Saharan Africa International Center of Excellence for Malaria Research, Tom Mboya University, Homa Bay, 40300, Kenya.
Kevin O OchwedoDepartment of Biology, University of Nairobi, Nairobi, 00100, Kenya.
Collince J OmondiDepartment of Biology, University of Nairobi, Nairobi, 00100, Kenya.
Simon M MuriuDepartment of Biological Sciences, Pwani University, Kilifi, 80108, Kenya.
David O OdongoDepartment of Biology, University of Nairobi, Nairobi, 00100, Kenya.
Horace OchandaDepartment of Biology, University of Nairobi, Nairobi, 00100, Kenya.
James KazuraCenter for Global Health and Disease, Case Western Reserve University, Cleveland, OH, 44106, USA.
Andrew K GithekoSub-Saharan Africa International Center of Excellence for Malaria Research, Tom Mboya University, Homa Bay, 40300, Kenya.
Guiyun YanProgram in Public Health, College of Health Sciences, University of California at Irvine, Irvine, CA, 92697, USA. guiyuny@uci.edu.
University of California, Irvine · USUniversity of Nairobi · KECase Western Reserve University · USJomo Kenyatta University of Agriculture and Technology · KEKenya Medical Research Institute · KEPwani University · KE

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Vector Biology of Invasive Anopheles stephensi in Rural to Urban Landscapes in EthiopiaU19AI129326 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Guiyun Yan · 2017 to 2026
$19.9M
Research Training in Mosquito Genomics and Bioinformat*D43TW001505 · FIC · UNIVERSITY OF CALIFORNIA-IRVINE · PI Guiyun Yan · 2000 to 2026
$6.0M
FIC NIH HHS D43 TW001505NCATS NIH HHS UL1 TR001414NIAID NIH HHS U19 AI129326
6 · The paper itself

Abstract

backgroundMalaria in western Kenya is currently characterized by sustained high Plasmodial transmission and infection resurgence, despite positive responses in some areas following intensified malaria control interventions since 2006. This study aimed to evaluate long-term changes in malaria transmission profiles and to assess patterns of asymptomatic malaria infections in school children aged 5-15 years at three sites in western Kenya with heterogeneous malaria transmission and simultaneous malaria control interventions.

methodsThe study was conducted from 2018 to 2019 and is based on data taken every third year from 2005 to 2014 during a longitudinal parasitological and mosquito adult surveillance and malaria control programme that was initiated in 2002 in the villages of Kombewa, Iguhu, and Marani. Plasmodium spp. infections were determined using microscopy. Mosquito samples were identified to species and host blood meal source and sporozoite infections were assayed using polymerase chain reaction.

resultsPlasmodium falciparum was the only malaria parasite evaluated during this study (2018-2019). Asymptomatic malaria parasite prevalence in school children decreased in all sites from 2005 to 2008. However, since 2011, parasite prevalence has resurged by > 40% in Kombewa and Marani. Malaria vector densities showed similar reductions from 2005 to 2008 in all sites, rose steadily until 2014, and decreased again. Overall, Kombewa had a higher risk of infection compared to Iguhu (χ

conclusionsMalaria prevalence in western Kenya remains high and has resurged in some sites despite continuous intervention efforts. Targeting malaria interventions to those with asymptomatic infections who serve as human reservoirs might decrease malaria transmission and prevent resurgences. Longitudinal monitoring enables detection of changes in parasitological and entomological profiles and provides core baseline data for the evaluation of vector interventions and guidance for future planning of malaria control.

Indexed as

AnophelesMalariaMalaria, FalciparumAnimalsChildFemaleHumansKenyaMaleMosquito VectorsPlasmodium falciparumProspective StudiesSexismMalariaPlasmodium falciparumResurgenceTransmission

Identifiers

PMID36352453
PMCPMC9647947
OpenAlexW4308624809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.