ArticleBMC biology2022
Molecular, cellular and neurological consequences of infection by the neglected human pathogen Nocardia.
Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- A landscape of epidemiology and strain distribution ofBiosafety and health · 2026Article
- Molecular mechanisms underlyingFrontiers in cellular and infection microbiology · 2026Review
- Case Report of a Solitary Brain Abscess due toCase reports in infectious diseases · 2026Article
- Advances in the molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2026Review
- Research progress on clinical challenges and prevention strategies of drug-resistantFrontiers in public health · 2026Review
- First reported case of abdominal Nocardia pseudocyst in the setting of a ventriculoperitoneal shunt: a case report and review of literature.Journal of medical case reports · 2025Review
- Nitric Oxide Contributes to the Pathogenesis ofMicroorganisms · 2025Article
- Intratracheal Aerosolization ofBiomolecules · 2025Article
- PD-Like Pathogenesis in Caenorhabditis elegans Intestinally Infected with Nocardia farcinica and the Underlying Molecular Mechanisms.Molecular neurobiology · 2025Article
- Genomic and phenotypic characterization of antimicrobial resistance in clinicalFrontiers in cellular and infection microbiology · 2025Article
- Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS inmSystems · 2024Article
- Infection route influence the consequences of Nocardia farcinica infection in BALB/c mice.BMC infectious diseases · 2024Article
- Epidemiology, Timing, and Secondary Prophylaxis of Recurrent Nocardiosis.Open forum infectious diseases · 2024Article
- Exploring Nocardia's ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors.Archives of microbiology · 2024Article
- Outcomes of transplant recipients with pretransplant Nocardia colonization or infection.Transplant infectious disease : an official journal of the Transplantation Society · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNocardia is a facultative intracellular pathogen that infects the lungs and brains of immunocompromised patients with consequences that can be fatal. The incidence of such infections is rising, immunocompetent individuals are also being infected, and there is a need to learn more about this neglected bacterial pathogen and the interaction with its human host.
resultsWe have applied dual RNA-seq to assess the global transcriptome changes that occur simultaneously in Nocardia farcinica (N. farcinica) and infected human epithelial alveolar host cells, and have tested a series of mutants in this in vitro system to identify candidate determinants of virulence. Using a mouse model, we revealed the profiles of inflammation-related factors in the lung after intranasal infection and confirmed that nbtB and nbtS are key virulence genes for Nocardia infection in vivo. Regarding the host response to infection, we found that the expression of many histones was dysregulated during the infection of lung cells, indicating that epigenetic modification might play a crucial role in the host during Nocardia infection. In our mouse model, Nocardia infection led to neurological symptoms and we found that 15 of 22 Nocardia clinical strains tested could cause obvious PD-like symptoms. Further experiments indicated that Nocardia infection could activate microglia and drive M1 microglial polarization, promote iNOS and CXCL-10 production, and cause neuroinflammation in the substantia nigra, all of which may be involved in causing PD-like symptoms. Importantly, the deletion of nbtS in N. farcinica completely attenuated the neurological symptoms.
conclusionsOur data contribute to an in-depth understanding of the characteristics of both the host and Nocardia during infection and provide valuable clues for future studies of this neglected human pathogen, especially those addressing the underlying causes of infection-related neurological symptoms.
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