Evidence map›Paper›PMID 36352359›Full record

Observational studyBMC infectious diseases2022

SARS-Cov-2 incubation period according to vaccination status during the fifth COVID-19 wave in a tertiary-care center in Spain: a cohort study.

Jordi Cortés Martínez, Daewoo Pak, Gabriela Abelenda-Alonso, Klaus Langohr, Jing Ning, Alexander Rombauts, Mireia Colom, Yu Shen, Guadalupe Gómez Melis

Abstract readObservational Study
In one paragraph

Observational study in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordi Cortés MartínezDepartment of Statistics and Operations Research, Universitat Politècnica de Catalunya, BarcelonaTech (UPC), 08034, Barcelona, Spain. jordi.cortes-martinez@upc.edu.
Daewoo PakDivision of Data Science, Yonsei University, Wonju, 26493, Korea.
Gabriela Abelenda-AlonsoDepartment of Infectious Diseases, Bellvitge University Hospital, 08907, L'Hospitalet De Llobregat, Spain.
Klaus LangohrDepartment of Statistics and Operations Research, Universitat Politècnica de Catalunya, BarcelonaTech (UPC), 08034, Barcelona, Spain.
Jing NingDepartment of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Alexander RombautsDepartment of Infectious Diseases, Bellvitge University Hospital, 08907, L'Hospitalet De Llobregat, Spain.
Mireia ColomBellvitge Biomedical Research Institute (IDIBELL), 08907, L'Hospitalet De Llobregat, Spain.
Yu ShenDepartment of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Guadalupe Gómez MelisDepartment of Statistics and Operations Research, Universitat Politècnica de Catalunya, BarcelonaTech (UPC), 08034, Barcelona, Spain.

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2020PANDE00148Departament d'Empresa i Coneixement, Generalitat de Catalunya 2017SGR622Ministerio de Ciencia e Innovación,Spain PID2019-104830RB-I00National Research Foundation of Korea 2021R1G1A1009269
6 · The paper itself

Abstract

backgroundThe incubation period of an infectious disease is defined as the elapsed time between the exposure to the pathogen and the onset of symptoms. Although both the mRNA-based and the adenoviral vector-based vaccines have shown to be effective, there have been raising concerns regarding possible decreases in vaccine effectiveness for new variants and variations in the incubation period.

methodsWe conducted a unicentric observational study at the Hospital Universitari de Bellvitge, Barcelona, using a structured telephone survey performed by trained interviewers to estimate the incubation period of the SARS-CoV-2 Delta variant in a cohort of Spanish hospitalized patients. The distribution of the incubation period was estimated using the generalized odds-rate class of regression models.

resultsFrom 406 surveyed patients, 242 provided adequate information to be included in the analysis. The median incubation period was 2.8 days (95%CI: 2.5-3.1) and no differences between vaccinated and unvaccinated patients were found. Sex and age are neither shown not to be significantly related to the COVID-19 incubation time.

conclusionsKnowing the incubation period is crucial for controlling the spread of an infectious disease: decisions on the duration of the quarantine or on the periods of active monitoring of people who have been at high risk of exposure depend on the length of the incubation period. Furthermore, its probability distribution is a key element for predicting the prevalence and the incidence of the disease.

Indexed as

COVID-19SARS-CoV-2Cohort StudiesHumansInfectious Disease Incubation PeriodSpainVaccinationAdenovirus-based vaccineCOVID-19Delta variantGeneralized odds-rate class of modelsIncubation periodInfectious disease

Identifiers

PMID36352359
PMCPMC9645305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.