Evidence map›Paper›PMID 36352356›Full record

ArticleBMC infectious diseases2022

Comparison of the duration of viral RNA shedding and anti-SARS-CoV-2 spike IgG and IgM antibody titers in COVID-19 patients who were vaccinated with inactivated vaccines or not: a retrospective study.

Chuancai Xu, Zhisong He, Wei Lei, Li Chen, Dan Shen, Xiaofei Wang, Deyu Xu, Ying Xu, Jian'an Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chuancai Xu *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Zhisong He *Department of Cardiology, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Wei Lei *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Li ChenDepartment of Infectious Diseases, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Dan ShenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Xiaofei WangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Deyu XuDepartment of Nephrology, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China.
Ying XuDepartment of Infectious Diseases, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China. 598438875@qq.com.
Jian'an HuangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, NO. 899, Pinghai Street, Suzhou, 215006, China. Huang_jian_an@163.com.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CN

Funding

the Clinical Medical Expert Team project of Suzhou City No. SZYJTD201801the Gusu youth medical talent GSWS2020017the Jiangsu Provincial Key Medical Discipline (Laboratory) No. ZDXKB2016007the Societal and Developmental Project of Suzhou City SYS2020008
6 · The paper itself

Abstract

backgroundAt present, the role of inactivated vaccines in viral RNA shedding among Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) breakthrough infections is still unknown.

methodsWe collected data of 147 coronavirus disease 2019 (COVID-19) patients with mild-to-moderate illness who were hospitalized in the Third People's Hospital of Yangzhou from 7 to 20 August 2021 and analyzed the differences in symptoms and laboratory tests among fully vaccinated (FV), partially vaccinated (PV) and unvaccinated (UV) patients.

resultsThe median duration of viral RNA shedding was shorter in the FV (12 [IQR, 9.5-14] days) and PV (13 [IQR, 9-16.75] days) groups than in the UV group (15 [IQR, 11.75-17.25] days) (adjusted P < 0.001 and adjusted P = 0.23, respectively). The median titers of SARS-CoV-2-specific IgG and IgM were significantly higher in the FV (12.29 S/co [IQR, 2.08-63.59] and 0.3 S/co [IQR, 0.05-2.29], respectively) and PV (0.68 S/co [IQR, 0.14-28.69] and 0.12 S/co [0.03-5.23], respectively) groups than in the UV group (0.06 S/co [IQR, 0.03-0.47] and 0.04 S/co [IQR, 0.02-0.07]) (adjusted P < 0.001 and adjusted P = 0.008, respectively).

conclusionsInactivated vaccines may shorten viral RNA shedding in breakthrough infected patients who have mild-to-moderate illness and may improve the ability of the host to generate specific antibodies to infection.

Indexed as

COVID-19Antibodies, ViralHumansImmunoglobulin GImmunoglobulin MRetrospective StudiesRNA, ViralSARS-CoV-2Vaccines, InactivatedAntibodies, ViralImmunoglobulin GImmunoglobulin MRNA, ViralVaccines, InactivatedBreakthrough infectionInactivated vaccineSARS-CoV-2SARS-CoV-2-specific IgGSARS-CoV-2-specific IgMViral RNA shedding

Identifiers

PMID36352356
PMCPMC9645737
OpenAlexW4308628190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.