ArticleNature2022
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.
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201citing papers in PubMed
27.9field-weighted citation impact, top 1% of its field
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Who cites it
201 citing papers in PubMed, 303 citations in OpenAlex.
- Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson's disease.The Journal of experimental medicine · 2026Article
- Cytokine circuits in CNS homeostasis and disease.Nature immunology · 2026Review
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- Maresin1 Improves Angiogenesis and Cognitive Function by Regulating Perivascular Macrophages in Rats with Chronic Cerebral Hypoperfusion.Neurochemical research · 2026Article
- Microglial states revisited: from homeostasis to disease.Nature reviews. Neuroscience · 2026Review
- Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice.Nature communications · 2026Article
- Article
- Border-Associated Macrophage Migrasomes in Alzheimer's Disease: An Emerging Aβ-Senescence-Microglia Axis?Cells · 2026Review
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Neural modulation of ocular immunity: Exploring a sympathetic-macrophage neuroimmune link in the human ciliary body.Journal of anatomy · 2026Article
- Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels.Nature neuroscience · 2026Article
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Review
- Article
- Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.Science immunology · 2026Article
- Serial failure of the brain clearance continuum in Alzheimer's disease: mechanisms and therapeutic perspectives.Journal of neurology · 2026Review
- Passive amyloid-β immunotherapy in Alzheimer's disease: a multicellular clearance system beyond plaque removal.Molecular neurodegeneration · 2026Review
- Early glymphatic failure in AppNL-F knock-in mice is linked to parenchymal border macrophages loss.Brain : a journal of neurology · 2026Article
- Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer's disease mouse models.Molecular psychiatry · 2026Article
141 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 20 institutions in 5 countries.
Antoine DrieuCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA. drieu@wustl.edu.ORCID http://orcid.org/0000-0001-6237-4719
Siling Du *Center for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.
Steffen E Storck *Center for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6965-2264
Justin Rustenhoven *Center for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.
Zachary PapadopoulosCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-5681-1388
Taitea DykstraCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-7756-809X
Fenghe ZhongDepartment of Biomedical Engineering, Danforth Campus, Washington University in St Louis, St Louis, MO, USA.
Kyungdeok KimCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.
Susan BlackburnCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.
Tornike MamuladzeCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-7088-3967
Oscar HarariDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-2635-6975
Celeste M KarchDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6854-5547
Randall J BatemanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-7729-1702
Richard PerrinDepartment of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3443-7716
Martin FarlowIndiana School of Medicine, Indianapolis, IN, USA.
Jasmeer ChhatwalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7792-1698
Dominantly Inherited Alzheimer Network
Song HuDepartment of Biomedical Engineering, Danforth Campus, Washington University in St Louis, St Louis, MO, USA.
Gwendalyn J RandolphDepartment of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-9045-1195
Igor SmirnovCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA.
Jonathan KipnisCenter for Brain Immunology and Glia (BIG), Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.ORCID http://orcid.org/0000-0002-3714-517X
Washington University in St. Louis · USGerman Center for Neurodegenerative Diseases · DEUniversity of Pittsburgh · USEmory University · USEdith Cowan University · AUIndiana University – Purdue University Indianapolis · USNiigata University · JPColumbia University · USJacksonville College · USUniversity College London · GBIcahn School of Medicine at Mount Sinai · USLudwig-Maximilians-Universität München · DEOsaka City University · JPUniversity of Southern California · USNeuroscience Research Australia · AUThe University of Melbourne · AUUniversity of Michigan · USBrigham and Women's Hospital · USBrown University · USHarvard University · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MDominantly Inherited Alzheimer NetworkUF1AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2017
$21.6MThe protein tyrosine kinase SYK drives innate immune responses against Alzheimer's DiseaseP01AG078106 · NIA · WASHINGTON UNIVERSITY · PI Jonathan Kipnis · 2022 to 2026
$18.4MTrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0MImaging CoreU01AG032438 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2008 to 2009
$6.1MNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R37 AI049653NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P01 AG078106NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG034113NIA NIH HHS R01 AG057777NIA NIH HHS R01 AG062734NIA NIH HHS R37 AG034113NIA NIH HHS R56 AG067764NIA NIH HHS RF1 AG057496NIA NIH HHS U01 AG032438NIA NIH HHS U19 AG032438NIA NIH HHS U24 AG021886NIA NIH HHS UF1 AG032438NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766NINDS NIH HHS R01 NS092865
Abstract
Macrophages are important players in the maintenance of tissue homeostasis
Indexed as
Central Nervous SystemCerebrospinal FluidMacrophagesParenchymal TissueAgingAlzheimer DiseaseAnimalsBrainCD163 AntigenEndocytosisExtracellular Matrix ProteinsHumansInterferon-gammaMeningesMicePhagocytosisCD163 AntigenExtracellular Matrix ProteinsInterferon-gammaLYVE1 protein, humanVesicular Transport Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.