ArticleNature2022
Spatial genomics maps the structure, nature and evolution of cancer clones.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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118citing papers in PubMed
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Who cites it
118 citing papers in PubMed.
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review).Oncology reports · 2026Review
- A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape.Nature ecology & evolution · 2026Article
- A guide to understanding tumour evolution through the lens of population genetics.Nature reviews. Cancer · 2026Review
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Benchmarking copy number alteration inference methods for spatial transcriptomics.Nature communications · 2026Article
- Spatial Integration of Protein and Chromosomal States Reveals Early Copy-Number Changes and Genotype-Associated Immune Neighborhoods in Serous Ovarian Cancer Evolution.Cancer discovery · 2026Article
- Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.Nature genetics · 2026Article
- Spatial omics illuminates tumor heterogeneity.Cell reports methods · 2026Review
- Agent-Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phylogeography of Bone Metastasis: Clonal Evolution, Skeletal Niche Adaptation, and Clinical Implications.International journal of molecular sciences · 2026Review
- Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.Nature biotechnology · 2026Article
- Tumor heterogeneity: development, mechanisms, and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- STGBench: sequencing-level spatial DNA-RNA simulation for multimodal and virtual cell-oriented benchmarking of genomic alterations.Briefings in bioinformatics · 2026Article
- Single cell spatial transcriptomics track the evolutionary hierarchy and microenvironment remodeling during breast carcinoma invasion.Nature communications · 2026Article
- Beyond Color: Hybrid Vibrational-Electronic Broadband Coherent Anti-Stokes Raman Scattering for Molecularly Informed Digital Pathology.Analytical chemistry · 2026Article
- Geospatial genetic evolution and phenotypic plasticity in triple-negative breast cancer.Genome medicine · 2026Article
- Spatial profiling of gene editing by in situ sequencing in mice and macaques.Nature biomedical engineering · 2026Article
- Revisiting nature of stage III non-small cell lung cancer: Anatomically defined, biologically systemic.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Review
58 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors.
Artem Lomakin *European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID http://orcid.org/0000-0002-6568-9668
Jessica Svedlund *Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden.
Carina StrellScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden.
Milana GataricEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Artem ShmatkoDivision of AI in Oncology, German Cancer Research Centre DKFZ, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2184-0856
Gleb RukhovichWellcome Sanger Institute, Hinxton, UK.
Jun Sung ParkEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID http://orcid.org/0000-0001-7149-6769
Young Seok JuLaboratory of Cancer Genomics, GSMSE, KAIST, Daejeon, Korea.ORCID http://orcid.org/0000-0002-5514-4189
Stefan DentroEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID http://orcid.org/0000-0002-0478-9729
Vitalii KleshchevnikovWellcome Sanger Institute, Hinxton, UK.
Vasyl VaskivskyiWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-4080-4965
Tong LiWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-8240-4476
Omer Ali BayraktarWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-6055-277X
Sarah PinderGuys and St Thomas' NHS Trust, London, UK.ORCID http://orcid.org/0000-0003-4167-8910
Andrea L RichardsonDepartment of Pathology, John Hopkins Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5221-1094
Sandro SantagataDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7528-9668
Peter J CampbellWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3921-0510
Hege RussnesDepartment of Pathology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Moritz GerstungEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK. moritz.gerstung@dkfz.de.ORCID http://orcid.org/0000-0001-6709-963X
Mats NilssonScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden. mats.nilsson@scilifelab.se.ORCID http://orcid.org/0000-0001-9985-0387
Lucy R YatesWellcome Sanger Institute, Hinxton, UK. ly2@sanger.ac.uk.ORCID http://orcid.org/0000-0003-4519-7794
Funding
Tissue and Pathology CoreP50CA168504 · NCI · DANA-FARBER CANCER INST · PI Nabihah Tayob · 2013 to 2026
$30.1MSystems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule DrugsU54CA225088 · NCI · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2018 to 2022
$10.8MNCI NIH HHS P50 CA168504NCI NIH HHS U54 CA225088Wellcome TrustWellcome Trust 108413/A/15/DWellcome Trust 214584/Z/18/Z
Abstract
Genome sequencing of cancers often reveals mosaics of different subclones present in the same tumour
Indexed as
Breast NeoplasmsCarcinoma, Intraductal, NoninfiltratingClonal EvolutionClone CellsGenomicsAlgorithmsFemaleHumansMicrodissectionMutationReproducibility of ResultsTranscriptomeTumor MicroenvironmentWhole Genome Sequencing
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.