Evidence map›Paper›PMID 36352208›Full record

ArticleJournal of applied genetics2023

No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise.

Witold Józef Światowy, Jacek Zieliński, Maria Aleksandra Osielska, Krzysztof Kusy, Dariusz Wieliński, Andrzej Pławski, Paweł Piotr Jagodziński

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Witold Józef ŚwiatowyDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781, Poznan, Poland. witoldswiatowy@gmail.com.ORCID http://orcid.org/0000-0002-9449-1976
Jacek ZielińskiDepartment of Athletics Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland.ORCID http://orcid.org/0000-0002-2782-9973
Maria Aleksandra OsielskaDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781, Poznan, Poland.ORCID http://orcid.org/0000-0002-1160-3216
Krzysztof KusyDepartment of Athletics Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland.ORCID http://orcid.org/0000-0003-1191-5524
Dariusz WielińskiDepartment of Anthropology and Biometry, Poznan University of Physical Education, Krolowej Jadwigi 27/39, 61-871, Poznan, Poland.ORCID http://orcid.org/0000-0002-6266-7164
Andrzej PławskiDepartment of General, Endocrinological Surgery and Gastroenterological Oncology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland.ORCID http://orcid.org/0000-0002-0534-8941
Paweł Piotr JagodzińskiDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781, Poznan, Poland. pjagodzi@ump.edu.pl.ORCID http://orcid.org/0000-0002-9046-6802
Poznan University of Medical Sciences · PL

Funding

Narodowe Centrum Nauki 2013/09/B/NZ7/02556Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu 2647
6 · The paper itself

Abstract

Physical exercise results in structural remodeling in tissues and modifies cellular metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic changes are one of the factors responsible for such exercise-related alterations. One-hour acute exercise will change DNMT1, HDAC1, and JHDM1D transcriptions in PBMC. This study examined changes in the expression of genes responsible for epigenetic modifications (HDAC1, DNMT1, and JHDM1D) during and after an incremental exercise test on a treadmill and a 30-min recovery. Blood samples from 9 highly trained triathletes were tested. Examination of the transcripts showed no significant changes. Correlations between transcript results and biochemical indices revealed a significant (p = 0.007) relationship between JHDM1D mRNA and the number of monocytes at peak exercise intensity (exhaustion), while there was no significant (p = 0.053) correlation at rest. There are no rapid changes in the mRNA levels of the genes studied in blood cells in competitive athletes during acute exercise and recovery. Due to the small group of subjects studied, more extensive research is needed to verify correlations between transcription and biochemical variables.

Indexed as

ExerciseLeukocytes, MononuclearEpigenesis, GeneticHumansRNA, MessengerRNA, MessengerAcute exerciseDNA methylationDNMT1EpigeneticHDAC1JHDM1D

Identifiers

PMID36352208
PMCPMC9836983
OpenAlexW4308687626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.