ArticleScientific reports2022
Stent-based electrode for radiofrequency ablation in the rat esophagus: a preliminary study.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Endoluminal photodynamic therapy with a photoreactive stent-based catheter system to treat malignant colorectal obstruction.Bioengineering & translational medicine · 2025Article
- Repeatable Photoactive Stent-Based Catheter to Enhance Therapeutic Efficacy for Esophageal Carcinoma.Biomaterials research · 2025Article
- Radiofrequency ablation with sine and square electrical waveforms to enhance ablation range.Frontiers in bioengineering and biotechnology · 2024Article
- Effects of changes in the waveform and frequency of radio frequency energy on tissue ablation range.PloS one · 2024Article
- Benign esophageal stricture model construction and mechanism exploration.Scientific reports · 2023Article
- Radiofrequency ablation via an implanted self-expandable metallic stent to treat in-stent restenosis in a rat gastric outlet obstruction model.Frontiers in bioengineering and biotechnology · 2023Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoluminal radiofrequency (RF) ablation has been widely used as a safe and effective treatment for Barrett's esophagus. However, inadequate RF ablation may occur due to insufficient contact between the electrode and target tissues. Herein, a stent-based monopolar RF electrode (SE) was developed to evenly deliver RF energy to the inner wall of the rat esophagus. The optimal RF parameters were evaluated in the exposed rat esophagus. The temperature in the rat esophagus reached 70 ℃ in 89 s at 30 W, 59 s at 40 W, and 34 s at 50 W. The technical feasibility and efficacy of RF ablation using SE were evaluated based on changes in histological transformation and immunohistochemical parameters of tissues compared at immediately, 1 and 2 weeks after the procedure. The degrees of inflammatory cell infiltration, fibrotic changes, TUNEL, and HSP70 in the RF-ablated rat esophagus were significantly higher than compared with sham control (all p < 0.05). TUNEL-positive deposition gradually decreased, but HSP 70-positive deposition maintained a similar level for 2 weeks. The stent-based RF ablation was technically feasible and effective in evenly inducing thermal damages to the rat esophagus. The RF ablation system using the SE may represent a promising treatment for endoluminal malignancies.
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