Evidence map›Paper›PMID 36352009›Full record

ArticleCommunications medicine2022

Genetic determinants for the racial disparities in the risk of prostate and testicular cancers.

Ivie Uzamere, Yinqiao Wang, Tongzhang Zheng, Yong Zhu

Open access · goldAbstract read
In one paragraph

Article in Communications medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ivie Uzamere *Department of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT, 06520, USA.
Yinqiao Wang *Department of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT, 06520, USA.
Tongzhang ZhengDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, 02912, USA.
Yong ZhuDepartment of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT, 06520, USA. yong.zhu@yale.edu.ORCID http://orcid.org/0000-0002-6957-1114
Yale University · USBrown University · US

Funding

Summer Research Experience in Environmental Health (SREEH)R25ES029052 · NIEHS · YALE UNIVERSITY · PI Caroline Helen Johnson, VASILIS VASILIOU · 2019 to 2026
$771k
Explore piRNA as a novel therapeutics for hepatocellular carcinomaR21CA238100 · NCI · YALE UNIVERSITY · PI ZHU, YONG · 2019 to 2020
$401k
NCI NIH HHS R21 CA238100NIEHS NIH HHS R25 ES029052U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA238100U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ES029052
6 · The paper itself

Abstract

backgroundA worldwide higher incidence of prostate cancer and lower incidence of testicular cancer in men of African ancestry compared to European ancestry has been observed previously. However, underlying mechanisms accounting for these observations are largely unknown.

methodsThe current study analyzed previously reported SNPs associated with either prostate cancer or testicular cancer to examine whether the risk allele frequency could help us understand the observed incidence disparities in men of African ancestry and European ancestry. Both t-test and regression analysis were performed.

resultsHere we show that men of African ancestry are more likely to have risk alleles of prostate cancer and less likely to have risk alleles of testicular cancer compared to men of European ancestry.

conclusionsOur findings suggest that genetic factors may play an important role in the racial disparities in the risk of prostate and testicular cancers.

Identifiers

PMID36352009
PMCPMC9630379
OpenAlexW4308147218

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.