Evidence map›Paper›PMID 36352003›Full record

ArticleScientific reports2022

Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes.

Neil White, Harini Sadeeshkumar, Anna Sun, Narasimhan Sudarsan, Ronald R Breaker

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Design and discovery of 'tug-of-war' riboswitches.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Lithium in plants.The New phytologist · 2025
    Review
  5. Article
  6. Genomic and metabolic characterization ofApplied and environmental microbiology · 2025
    Article
  7. Review
  8. The current riboswitch landscape inMicrobiology (Reading, England) · 2024
    Review
  9. Article
  10. Riboswitches, from cognition to transformation.Synthetic and systems biotechnology · 2023
    Review
  11. Discovering riboswitches: the past and the future.Trends in biochemical sciences · 2023
    Review
  12. NaNature chemical biology · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Neil WhiteDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520-8103, USA.
Harini SadeeshkumarDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520-8103, USA.
Anna SunDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520-8103, USA.
Narasimhan SudarsanHoward Hughes Medical Institute, Yale University, New Haven, CT, 06520-8103, USA.
Ronald R BreakerDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520-8103, USA. ronald.breaker@yale.edu.
Yale University · USHoward Hughes Medical Institute · US

Funding

X-RAY ANALYSIS OF PROTEIN STRUCTURE AND FUNCTIONP01GM022778 · NIGMS · YALE UNIVERSITY · PI BREAKER, RONALD R · 1985 to 2019
$26.1M
Exploiting Riboswitch Sensors to Reveal Antibiotics Uptake and Retention in Gram Negative BacteriaR01AI136794 · NIAID · YALE UNIVERSITY · PI BREAKER, RONALD R, KAZMIERCZAK, BARBARA I · 2018 to 2022
$5.6M
Discovery and Characterization of New RiboswitchesR01GM136969 · NIGMS · YALE UNIVERSITY · PI STROBEL, SCOTT A · 2020 to 2023
$1.6M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI136794NIGMS NIH HHS P01 GM022778NIGMS NIH HHS R01 GM136969
6 · The paper itself

Abstract

Lithium is rare in Earth's crust compared to the biologically relevant alkali metal cations sodium and potassium but can accumulate to toxic levels in some environments. We report the experimental validation of two distinct bacterial riboswitch classes that selectively activate gene expression in response to elevated Li

Indexed as

RiboswitchBacteriaCationsGenes, BacterialLithiumMembrane Transport ProteinsSodiumCationsLithiumMembrane Transport ProteinsRiboswitchSodium

Identifiers

PMID36352003
PMCPMC9646797
OpenAlexW4308736572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.