Evidence map›Paper›PMID 36351987›Full record

ArticleScientific reports2022

Multi-organ segmentation of abdominal structures from non-contrast and contrast enhanced CT images.

Cenji Yu, Chidinma P Anakwenze, Yao Zhao, Rachael M Martin, Ethan B Ludmir, Joshua S Niedzielski, Asad Qureshi, Prajnan Das, Emma B Holliday, Ann C Raldow and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Anatomic Interactive Atlas of the Loggerhead Sea Turtle (Animals : an open access journal from MDPI · 2026
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  12. Automated Segmentation of Lymph Nodes on Neck CT Scans Using Deep Learning.Journal of imaging informatics in medicine · 2024
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  17. Automatic end-to-end VMAT treatment planning for rectal cancers.Journal of applied clinical medical physics · 2024
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cenji YuThe University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA. cyu4@mdanderson.org.
Chidinma P AnakwenzeDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yao ZhaoThe University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA.
Rachael M MartinDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ethan B LudmirDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Joshua S NiedzielskiDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Asad QureshiGuy's and St, Thomas' NHS Foundation Trust, London, UK.
Prajnan DasDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Emma B HollidayDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ann C RaldowDepartment of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, USA.
Callistus M NguyenDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Raymond P MummeDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tucker J NethertonDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dong Joo RheeDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Skylar S GayThe University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA.
Jinzhong YangThe University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA.
Laurence E CourtThe University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA.
Carlos E CardenasDepartment of Radiation Physics, The University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Manually delineating upper abdominal organs at risk (OARs) is a time-consuming task. To develop a deep-learning-based tool for accurate and robust auto-segmentation of these OARs, forty pancreatic cancer patients with contrast-enhanced breath-hold computed tomographic (CT) images were selected. We trained a three-dimensional (3D) U-Net ensemble that automatically segments all organ contours concurrently with the self-configuring nnU-Net framework. Our tool's performance was assessed on a held-out test set of 30 patients quantitatively. Five radiation oncologists from three different institutions assessed the performance of the tool using a 5-point Likert scale on an additional 75 randomly selected test patients. The mean (± std. dev.) Dice similarity coefficient values between the automatic segmentation and the ground truth on contrast-enhanced CT images were 0.80 ± 0.08, 0.89 ± 0.05, 0.90 ± 0.06, 0.92 ± 0.03, 0.96 ± 0.01, 0.97 ± 0.01, 0.96 ± 0.01, and 0.96 ± 0.01 for the duodenum, small bowel, large bowel, stomach, liver, spleen, right kidney, and left kidney, respectively. 89.3% (contrast-enhanced) and 85.3% (non-contrast-enhanced) of duodenum contours were scored as a 3 or above, which required only minor edits. More than 90% of the other organs' contours were scored as a 3 or above. Our tool achieved a high level of clinical acceptability with a small training dataset and provides accurate contours for treatment planning.

Indexed as

Organs at RiskTomography, X-Ray ComputedAbdomenHumansImage Processing, Computer-AssistedLiverPatient Care Planning

Identifiers

PMID36351987
PMCPMC9646761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.