Evidence map›Paper›PMID 36351971›Full record

ArticleScientific reports2022

Cerebellum-dependent associative learning is not impaired in a mouse model of neurofibromatosis type 1.

M J Ottenhoff, S Dijkhuizen, A C H Ypelaar, N L de Oude, S K E Koekkoek, S S-H Wang, C I De Zeeuw, Y Elgersma, H J Boele

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

M J OttenhoffDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
S DijkhuizenDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
A C H YpelaarDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
N L de OudeDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
S K E KoekkoekDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
S S-H WangNeuroscience Institute, Princeton University, Washington Road, Princeton, NJ, USA.
C I De ZeeuwDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands.
Y ElgersmaThe ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, 3015GD, The Netherlands.
H J BoeleDepartment of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands. hboele@princeton.edu.
Erasmus MC · NLErasmus University Rotterdam · NLPrinceton University · US

Funding

Imaging adaptive cerebellar processing at cellular resolution in awake miceR01NS045193 · NINDS · PRINCETON UNIVERSITY · PI WANG, SAMUEL SHENG-HUNG · 2003 to 2024
$7.5M
Cerebellar determinants of flexible and social behavior on rapid time scales in autism model mice.R01MH115750 · NIMH · PRINCETON UNIVERSITY · PI PILLOW, JONATHAN WILLIAM, SHAEVITZ, JOSHUA W · 2017 to 2021
$4.7M
Erasmus MC Fellowship 106958ERC-adv GA-294775ERC-POC 737619INTENSE LSH-NWO TTW/00798883Medical Neuro-Delta MD 01092019-31082023Netherlands Organization for Medical Sciences ZonMW 91120067Netherlands Organization for Scientific Research NWO-ALW 824.02.001Netherlands Organization for Scientific Research Veni ZonMW 91618112New Jersey Autism Center for Excellence Fellowship CAUT20AFP006NIH HHS R01 NS045193NIMH NIH HHS R01 MH115750NINDS NIH HHS R01 NS045193
6 · The paper itself

Abstract

Individuals with Neurofibromatosis type 1 (NF1) experience a high degree of motor problems. The cerebellum plays a pivotal role in motor functioning and the NF1 gene is highly expressed in cerebellar Purkinje cells. However, it is not well understood to what extent NF1 affects cerebellar functioning and how this relates to NF1 motor functioning. Therefore, we subjected global Nf1

Indexed as

Neurofibromatosis 1AnimalsBlinkingCerebellumConditioning, ClassicalMicePurkinje Cells

Identifiers

PMID36351971
PMCPMC9646701
OpenAlexW4308738485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.