Evidence map›Paper›PMID 36351910›Full record

ReviewNPJ Parkinson's disease2022

Microstructural but not macrostructural cortical degeneration occurs in Parkinson's disease with mild cognitive impairment.

Xueqin Bai, Tao Guo, Jingwen Chen, Xiaojun Guan, Cheng Zhou, Jingjing Wu, Xiaocao Liu, Haoting Wu, Jiaqi Wen, Luyan Gu and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2026
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  12. Cognitive impairment in Parkinson's disease and other parkinsonian syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Xueqin Bai *Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.ORCID http://orcid.org/0000-0002-9092-7824
Tao Guo *Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Jingwen ChenDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Xiaojun GuanDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.ORCID http://orcid.org/0000-0003-2313-4477
Cheng ZhouDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Jingjing WuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Xiaocao LiuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Haoting WuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Jiaqi WenDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Luyan GuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Ting GaoDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Min XuanDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Peiyu HuangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Baorong ZhangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.ORCID http://orcid.org/0000-0002-8099-7407
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.ORCID http://orcid.org/0000-0002-0127-2812
Minming ZhangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China. zhangminming@zju.edu.cn.ORCID http://orcid.org/0000-0003-0145-7558
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the cortical microstructural/macrostructural degenerative patterns in Parkinson's disease (PD) patients with mild cognitive impairment (MCI). Overall, 38 PD patients with normal cognition (PD-NC), 38 PD-MCI, and 32 healthy controls (HC) were included. PD-MCI was diagnosed according to the MDS Task Force level II criteria. Cortical microstructural alterations were evaluated with Neurite Orientation Dispersion and Density Imaging. Cortical thickness analyses were derived from T1-weighted imaging using the FreeSurfer software. For cortical microstructural analyses, compared with HC, PD-NC showed lower orientation dispersion index (ODI) in bilateral cingulate and paracingulate gyri, supplementary motor area, right paracentral lobule, and precuneus (P

Identifiers

PMID36351910
PMCPMC9646695
OpenAlexW4308603419

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.